ArticleMicrobiology spectrum2026
Neutrophil-specific transcriptomic profiling reveals a novel signature for active tuberculosis diagnosis.
Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Current laboratory diagnostics for tuberculosis: from conventional approaches to next-generation molecular and immunological technologies.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Review
- Mitochondrial dysfunction and the regulatory cell death crosstalk network in chronic obstructive pulmonary disease: from oxidative stress mechanisms to targeted therapeutic strategies.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Tuberculosis remains a leading cause of mortality worldwide. Rapid and accurate diagnosis of active tuberculosis (ATB) is critical for its effective treatment and disease control. However, current sputum-based detection methods have limited diagnostic coverage for ATB, resulting in missed cases and treatment delay. In this study, we performed neutrophil RNA sequencing (RNA-seq) to identify ATB-specific transcriptional signatures. Through integrated analysis of differentially expressed genes (DEGs) across 173 samples (67 ATB, 42 latent tuberculosis infection [LTBI], and 64 healthy controls [HC]), followed by quantitative Real-time polymerase chain reaction (qPCR) validation using 141 samples (31 ATB, 53 LTBI, 57 HC). A novel 4-gene neutrophil-derived tuberculosis signature (neu-TB) was screened by Lasso model prediction, and further evaluation were performed in two independent cohorts (
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Registered trials
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