Evidence map›Paper›PMID 41817033›Full record

ArticleChemistry & biodiversity2026

Cytotoxic, Genotoxic, and Mutagenic Effects of Organotellurane RF07 in Female Swiss Mice (Mus musculus).

Felipe Emannuel Alvino de Jesus, Octávio Augusto de Carvalho Maia, Rosália Maria Tôrres de Lima, Ag-Anne Pereira Melo de Meneses, Audinei de Sousa Moura, Antonielly Campinho Dos Reis, Maria Luísa Lima Barreto do Nascimento, Taline Alves Nobre, Athanara Alves de Sousa, Shamya Gabriella Corrêa Coelho and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Felipe Emannuel Alvino de JesusToxicological Genetics Research Laboratory - LAPGENIC, Federal University of Piauí. Teresina, Piauí, Brazil.
Octávio Augusto de Carvalho MaiaToxicological Genetics Research Laboratory - LAPGENIC, Federal University of Piauí. Teresina, Piauí, Brazil.
Rosália Maria Tôrres de LimaToxicological Genetics Research Laboratory - LAPGENIC, Federal University of Piauí. Teresina, Piauí, Brazil.
Ag-Anne Pereira Melo de MenesesToxicological Genetics Research Laboratory - LAPGENIC, Federal University of Piauí. Teresina, Piauí, Brazil.
Audinei de Sousa MouraToxicological Genetics Research Laboratory - LAPGENIC, Federal University of Piauí. Teresina, Piauí, Brazil.
Antonielly Campinho Dos ReisToxicological Genetics Research Laboratory - LAPGENIC, Federal University of Piauí. Teresina, Piauí, Brazil.
Maria Luísa Lima Barreto do NascimentoToxicological Genetics Research Laboratory - LAPGENIC, Federal University of Piauí. Teresina, Piauí, Brazil.
Taline Alves NobreToxicological Genetics Research Laboratory - LAPGENIC, Federal University of Piauí. Teresina, Piauí, Brazil.
Athanara Alves de SousaToxicological Genetics Research Laboratory - LAPGENIC, Federal University of Piauí. Teresina, Piauí, Brazil.
Shamya Gabriella Corrêa CoelhoToxicological Genetics Research Laboratory - LAPGENIC, Federal University of Piauí. Teresina, Piauí, Brazil.
Glissia Lysandra Dos Santos MarcielToxicological Genetics Research Laboratory - LAPGENIC, Federal University of Piauí. Teresina, Piauí, Brazil.
Isabela Ribeiro de Sá Guimarães NolêtoToxicological Genetics Research Laboratory - LAPGENIC, Federal University of Piauí. Teresina, Piauí, Brazil.
Adriana Maria Viana NunesDepartment of Biophysics and Physiology, Federal University of Piauí Teresina, Piauí, Brazil.
Rodrigo Luiz Oliveira Rodrigues CunhaCenter of Natural and Human Sciences, Federal University of ABC, Santo André, São Paulo, Brazil.
Pedro Marcos de AlmeidaHealth Sciences Center, State University of Piaui, Brazil.
Diego Di Felipe Ávila AlcantaraHuman Cytogenetics Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil.
João Marcelo de Castro E SousaToxicological Genetics Research Laboratory - LAPGENIC, Federal University of Piauí. Teresina, Piauí, Brazil.ORCID https://orcid.org/0000-0002-5085-1482

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The organotellurane RF07 (RF07) is an organic compound containing tellurium, a rare semi-metal, and its leishmanicidal and antimalarial activity has already been reported in previous studies. This study evaluated the toxic effects of RF07 at 0.42, 21.37, and 42.75 mg/kg using comet assay, micronucleus test, and hematological/biochemical tests in Mus musculus. Female Swiss mice received intraperitoneal RF07. Blood was collected at 24, 48, and 72 h, followed by euthanasia for bone marrow analysis. Results showed RF07 increased DNA damage, clastogenic/aneugenic effects via micronuclei formation, and cytotoxicity through apoptosis in bone marrow erythroid precursors and altering the ratio of polychromatic to normochromatic erythrocytes. RF07 also caused myelosuppression and hepatotoxicity. To our knowledge, this is the first study explore these toxic effects. However, the mechanism remains unclear, requiring further investigation.

Indexed as

MutagensOrganometallic CompoundsAnimalsApoptosisComet AssayDNA DamageDose-Response Relationship, DrugFemaleMiceMicronucleus TestsMutagensOrganometallic Compoundsapoptosiscomet assaymicronucleus testorganotelluranetoxic effects

Identifiers

PMID41817033
PMCPMC12980693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.