Evidence map›Paper›PMID 41817001›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

CBP/β-Catenin Signaling in Hepatocytes Plays Pivotal Roles in MMP-7-Mediated Liver Fibrosis in a Metabolic Dysfunction-Associated Steatohepatitis Mouse Model.

Jun Imamura, Masamichi Kimura, Yumi Otoyama, Koji Nishikawa, Michinori Kohara, Kiminori Kimura

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jun ImamuraDepartment of Hepatology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Masamichi KimuraDepartment of Hepatology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Yumi OtoyamaDepartment of Hepatology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Koji NishikawaDepartment of Hepatology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Michinori KoharaDepartment of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Kiminori KimuraDepartment of Hepatology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.ORCID https://orcid.org/0000-0002-9352-4721

Funding

Japan Agency for Medical Research and Development (AMED) 18pc0101024s0101Japan Agency for Medical Research and Development (AMED) 20ek0109457h0001Japan Agency for Medical Research and Development (AMED) 20lm0203057h0003
6 · The paper itself

Abstract

In this study, we focused on CBP/β-catenin signaling in hepatocytes and investigated its involvement in fibrosis in a metabolic dysfunction-associated steatohepatitis (MASH) model using a choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD). Alb-Cre/CBPKO (CBP

Indexed as

beta CateninCREB-Binding ProteinFatty LiverHepatocytesLiver CirrhosisMatrix Metalloproteinase 7AnimalsDiet, High-FatDisease Models, AnimalLiverMaleMiceMice, Inbred C57BLMice, KnockoutSignal Transductionbeta CateninCREB-Binding ProteinCrebbp protein, mouseMatrix Metalloproteinase 7cAMP response element‐binding protein‐binding proteinMASHMMP‐7P300Wnt/β‐catenin

Identifiers

PMID41817001
PMCPMC12980565

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.