Evidence map›Paper›PMID 41816993›Full record

SynthesisOral diseases2026

Efficacy and Safety of Intra-Articular Therapies for Temporomandibular Disorders: A Systematic Review and Meta-Analysis.

Mateus Gaya Dos Santos, Wellington Luiz de Oliveira da Rosa, Cristian Sbardelotto, Júlia Silva Gomes de Araújo, Camila da Silva Rodrigues, Noéli Boscato

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mateus Gaya Dos SantosGraduate Program in Dentistry, Federal University of Pelotas (UFPel), Pelotas, Brazil.
Wellington Luiz de Oliveira da RosaGraduate Program in Dentistry, Federal University of Pelotas (UFPel), Pelotas, Brazil.
Cristian SbardelottoGraduate Program in Dentistry, Federal University of Pelotas (UFPel), Pelotas, Brazil.
Júlia Silva Gomes de AraújoGraduate Program in Dentistry, Federal University of Pelotas (UFPel), Pelotas, Brazil.
Camila da Silva RodriguesDepartment of Dental Materials and Prosthodontics, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, Brazil.
Noéli BoscatoGraduate Program in Dentistry, Federal University of Pelotas (UFPel), Pelotas, Brazil.ORCID https://orcid.org/0000-0002-3817-1732

Funding

Conselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
6 · The paper itself

Abstract

objectiveThis systematic review and meta-analysis aimed to evaluate the most effective minimally invasive intra-articular procedure for reducing pain and improving maximum mouth opening (MMO) in individuals diagnosed with painful articular TMD, specifically TMJ osteoarthritis and/or internal derangement. MATERIALS AND

methodsOnly randomized clinical trials (RCTs) assessing the efficacy of minimally invasive procedures, such as arthrocentesis and intra-articular injection (IAI), were included. The meta-analysis included seven studies with a 6-month follow-up, while 23 studies with different follow-up periods were evaluated qualitatively.

resultsThe meta-analysis showed that IAI with tenoxicam was the most effective procedure for pain reduction, with the highest [7.44 mean difference (MD); 6.28-8.60 confidence interval (CI)], followed by opioids (5.93; 5.03-6.83), the combination of hyaluronic acid (HA) with platelet-rich plasma (PRP) (5.10; 4.52-5.68), and PRP alone (4.99; 3.13-6.85). For improvement in MMO, tenoxicam had the highest MD (+11.50 mm; 15.47-7.53), followed by PRP (+10.46 mm; 14.89-6.02) and the HA-PRP combination (+10.10 mm; 11.89-8.31).

conclusionsTenoxicam showed promising results for pain reduction and improvement in MMO, although the evidence remains limited, followed by opioids and the combination of HA and PRP with arthrocentesis. Further high-quality studies are needed to confirm their clinical applicability.

Indexed as

Temporomandibular Joint DisordersAnalgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalArthrocentesisHumansHyaluronic AcidInjections, Intra-ArticularOsteoarthritisPiroxicamPlatelet-Rich PlasmaRandomized Controlled Trials as TopicTreatment OutcomeAnalgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalHyaluronic AcidPiroxicamtenoxicamadverse eventsarthrocentesisintra‐articulartemporomandibular disordertemporomandibular joint

Identifiers

PMID41816993
PMCPMC13590907

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.