Evidence map›Paper›PMID 41816989›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence.

Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yueqi ZhangNational Key Laboratory of Rice Biological Breeding, Zhejiang University, Hangzhou, China.
Jingrui WangInstitute of Biotechnology, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, China.
Qiaowan ChenNational Key Laboratory of Rice Biological Breeding, Zhejiang University, Hangzhou, China.
Chen JiaoInstitute of Biotechnology, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, China.
Yun ChenNational Key Laboratory of Rice Biological Breeding, Zhejiang University, Hangzhou, China.
Zhongshou WuNational Key Laboratory of Rice Biological Breeding, Zhejiang University, Hangzhou, China.
Zhonghua MaNational Key Laboratory of Rice Biological Breeding, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0000-0002-5426-0997

Funding

China Agriculture Research System CARS-03-29National Key Research and Development Program of China 2022YFD1400100National Natural Science Foundation of China U21A20219
6 · The paper itself

Abstract

Understanding how fungi regulate mycotoxin production is critical for managing crop diseases and reducing contamination in food systems. Here, we elucidate the mechanism of the transcription factor FgSge1 in Fusarium graminearum, a significant fungal pathogen responsible for Fusarium head blight in cereal crops, in regulating mycotoxin biosynthesis and pathogenicity. FgSge1 specifically binds to the 8-bp cis-element TAARGTTT. Under mycotoxin-induced conditions, FgSge1 binds to this cis-element within its own promoter, activating its own transcription. Additionally, FgSge1 connects with this cis-element within the promoters of mycotoxin biosynthesis genes and interacts directly with the scaffold protein FgAda2 of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) complex. This interaction recruits the histone acetyltransferase FgGcn5 to the promoters of DON biosynthetic genes, promoting histone acetylation and facilitating jet-like chromatin architecture, thereby activating transcription. In contrast, the FgSge1 mutant fails to recruit the SAGA complex, leading to reduced histone acetylation, disrupted chromatin structure, and impaired DON biosynthesis. Together, these findings establish FgSge1 as a critical self-activating regulatory factor that links histone acetylation to higher-order chromatin remodeling, orchestrating mycotoxin gene activation, and providing a framework for understanding epigenetic control of mycotoxin biosynthesis and virulence in fungi.

Indexed as

Fungal ProteinsFusariumMycotoxinsTranscription FactorsGene Expression Regulation, FungalHistone AcetyltransferasesPlant DiseasesPromoter Regions, GeneticVirulenceFungal ProteinsHistone AcetyltransferasesMycotoxinsTranscription Factorschromatin conformationFusarium graminearumhistone acetylationmycotoxintranscription factor

Identifiers

PMID41816989
PMCPMC13205826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.