Evidence map›Paper›PMID 41816984›Full record

ArticleACS infectious diseases2026

Structure-Activity Relationships among Inhibitors of

Misgina Girma, Meagan Belcher Dufrisne, Archi Sehgal, Allyson Dailey, Kenneth Heidel, Darean Bague, Xu Wang, Logan Bartholomew, Richard Beck, Samuel Kirby and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Misgina GirmaGeorge Mason University, Chemistry and Biochemistry, 10920 George Mason Circle, Fairfax, Virginia 22030-4444, United States.
Meagan Belcher DufrisneWalter Reed Army Institute of Research, Bacterial Diseases Branch, Wound Infections Department, 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States.
Archi SehgalGeorge Mason University, Chemistry and Biochemistry, 10920 George Mason Circle, Fairfax, Virginia 22030-4444, United States.
Allyson DaileyGeorge Mason University, Chemistry and Biochemistry, 10920 George Mason Circle, Fairfax, Virginia 22030-4444, United States.
Kenneth HeidelThe George Washington University, Washington, District of Columbia 20052-0086, United States.
Darean BagueThe George Washington University, Washington, District of Columbia 20052-0086, United States.
Xu WangThe George Washington University, Washington, District of Columbia 20052-0086, United States.ORCID 0000-0001-7379-5789
Logan BartholomewThe George Washington University, Washington, District of Columbia 20052-0086, United States.
Richard BeckThe George Washington University, Washington, District of Columbia 20052-0086, United States.
Samuel KirbyThe George Washington University, Washington, District of Columbia 20052-0086, United States.
Haley BallGeorge Mason University, Chemistry and Biochemistry, 10920 George Mason Circle, Fairfax, Virginia 22030-4444, United States.
Mosufa ZainabGeorge Mason University, Chemistry and Biochemistry, 10920 George Mason Circle, Fairfax, Virginia 22030-4444, United States.
Soo Hyeon LeeWalter Reed Army Institute of Research, Bacterial Diseases Branch, Wound Infections Department, 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States.
Iswarduth SoojhawonWalter Reed Army Institute of Research, Bacterial Diseases Branch, Wound Infections Department, 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States.
Schroeder M NobleWalter Reed Army Institute of Research, Bacterial Diseases Branch, Wound Infections Department, 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States.
Cynthia S DowdThe George Washington University, Washington, District of Columbia 20052-0086, United States.
Robin D CouchDepartment of Chemistry and Biochemistry, George Mason University, Manassas, Virginia 20110, United States.ORCID 0000-0002-0364-1634

Funding

User Training & OutreachP30GM138396 · NIGMS · UCHICAGO ARGONNE, LLC · PI ROBERT F. FISCHETTI, JANET L. SMITH · 2020 to 2026
$34.3M
NIGMS NIH HHS P30 GM138396
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) is a critical global health crisis, responsible for nearly 5 million deaths in 2019 and projected to impose up to $100 trillion in economic costs by 2050. To address this threat, we are developing new antibiotics targeting the methylerythritol phosphate (MEP) pathway in

Indexed as

Acinetobacter baumanniiAldose-Ketose IsomerasesAnti-Bacterial AgentsEnzyme InhibitorsKlebsiella pneumoniaeMultienzyme ComplexesOxidoreductasesCrystallography, X-RayFosfomycinMicrobial Sensitivity TestsModels, MolecularStructure-Activity Relationship1-deoxy-D-xylulose 5-phosphate reductoisomeraseAldose-Ketose IsomerasesAnti-Bacterial AgentsEnzyme InhibitorsFosfomycinfosmidomycinMultienzyme ComplexesOxidoreductasesA. baumanniiAb-IspC-inhibitor crystalsDXR/IspCfosmidomycin analogsK. pneumoniaeMEP pathway

Identifiers

PMID41816984
PMCPMC13366575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.