Evidence map›Paper›PMID 41816965›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

APOE and plasma AD biomarkers: The role of genetic ancestry in Hispanics/Latinos.

Caitlin Cheung, Natasha Z Anita, Paola Filigrana, Myriam Fornage, Kevin A Gonzalez, Linda C Gallo, Carmen R Isasi, Robert C Kaplan, Xihao Li, Freddie Márquez and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Novel genetic profile linked to cognitive decline in Hispanics/Latinos.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Caitlin CheungDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Natasha Z AnitaDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
Paola FiligranaDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Kevin A GonzalezDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
Linda C GalloDepartment of Psychology, San Diego State University, San Diego, California, USA.
Carmen R IsasiDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Robert C KaplanDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Xihao LiDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Freddie MárquezDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
Humberto ParadaDivision of Epidemiology and Biostatistics, School of Public Health, San Diego State University, San Diego, California, USA.
Krista M PerreiraDepartment of Social Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Alberto R RamosDepartment of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, USA.
Tatjana RundekDepartment of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, USA.
Wassim TarrafDepartment of Healthcare Sciences, Institute of Gerontology, Wayne State University, Detroit, Michigan, USA.
Fernando D TestaiDepartment of Neurology and Rehabilitation, University of Illinois Chicago College of Medicine, Chicago, Illinois, USA.
Charles DeCarliDepartment of Neurology, University of California Davis, Sacramento, California, USA.
Hector M GonzálezDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
Tamar SoferDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Funding

Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's diseaseR01AG075758 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Charles DeCarli, Hector M Gonzalez · 2022 to 2026
$21.7M
Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA)R01AG048642 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GONZALEZ, HECTOR M · 2015 to 2019
$5.7M
Using polygenic risk scores and omics to study how suboptimal sleep accelerates cognitive aging in diverse populationsR01AG080598 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Tamar Sofer · 2023 to 2026
$3.6M
National Institute on Aging (NIA) R01AG048642National Institute on Aging (NIA) R01AG075758National Institute on Aging (NIA) R56AG048642NIA NIH HHS R01 AG048642NIA NIH HHS R01 AG075758NIA NIH HHS R01 AG080598
6 · The paper itself

Abstract

backgroundApolipoprotein E (APOE) alleles are well-established genetic risk factors for Alzheimer's disease (AD), but their effects on AD biomarkers (amyloid beta [Aβ]42/40, phosphorylated tau [p-tau]181, neurofilament light chain [NfL], and glial fibrillary acidic protein [GFAP]) may vary across populations due to ancestry-, age-, and sex-related differences. We hypothesized that these effects vary across Hispanic/Latino background groups with distinct ancestral admixture.

methodsWe analyzed ε2 and ε4 allele associations with AD biomarkers using survey-weighted linear regression models, adjusting for demographic covariates. Secondary analyses examined genetic analysis group- and ancestry-specific effects.

resultsε4 was associated with lower Aβ42/40 and higher p-tau181and GFAP levels, but not with NfL, suggesting its role in Aβ and tau deposition and neuroinflammation. ε4 associations were stronger in those with higher European and lower African ancestry. DISCUSSION: These findings expand on prior studies suggesting that genetic ancestry modifies APOE-associated AD risk in Hispanic/Latino populations and highlight the importance of capturing ancestry-based heterogeneity in AD biomarker research.

Indexed as

Alzheimer DiseaseApolipoprotein E4Apolipoproteins EHispanic or LatinoAfrican PeopleAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersFemaleGlial Fibrillary Acidic ProteinHumansMaleNeurofilament ProteinsPeptide Fragmentstau ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-40)amyloid beta-protein (1-42)Apolipoprotein E4Apolipoproteins EBiomarkersGFAP protein, humanGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament ProteinsPeptide Fragmentstau ProteinsAlzheimer's diseaseamyloid/tau/neurodegeneration frameworkapolipoprotein Egenetic ancestryHispanics/Latinosplasma biomarkers

Identifiers

PMID41816965
PMCPMC13093554

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