ArticleNucleic acids research2026
The yeast phosphofructokinase β-subunit has RNA unwinding activity and modulates cell cycle progression.
Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Mechanistic and applied study of phosphofructokinases, the "gatekeeper" of the glycolytic pathway on the central carbon metabolism.Metabolic engineering communications · 2026Article
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Authors and funding
11 authors.
Funding
Abstract
Phosphofructokinase (PFK) is a rate-limiting glycolytic enzyme that also possesses an unexplored RNA binding activity. Here, we show that the α- and β-subunits of yeast PFK, encoded by PFK1 and PFK2, respectively, bind hundreds of functionally related messenger RNAs (mRNAs) in cells, including one's coding for proteins involved in the regulation of mitotic cell cycle. Both Pfk1p and Pkf2p directly bind to short GA-, UC-, AU-, and U-rich motifs overrepresented in their mRNA targets. Strikingly, Pfk2p displays directional 5'-3' double-stranded RNA unwinding activity not seen with Pfk1p. Furthermore, Pfk2p dynamically associates with ribosomes and promotes translation of cell cycle genes. Consequently, pfk2∆, but not pfk1∆, mutants display increased cell sizes and severely delayed G1/S phase transition, independent of the enzyme's glycolytic activity. Our results uncovered a hidden function for the Pfk2 subunit as a translational activator of mitotic cell cycle gene transcripts possibly through energy-dependent RNA unwinding activity, thus providing a link between central energy metabolism and cell proliferation.
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