ArticleJournal of materials chemistry. B2026
Scalable one-step synthesis of gelatin-dithiolane for neural tissue engineering.
Article in Journal of materials chemistry. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Protein-based hydrogels crosslinked using dithiolanes provide a promising viscoelastic matrix for soft tissue engineering and regenerative medicine including the neural niches due to their inherent biocompatibility, bioactivity, and adaptable extracellular matrix (ECM)-like viscoelastic behavior. Recently, we developed gelatin-dithiolane (GelDT) as a new class of ECM-mimicking viscoelastic hydrogels that displayed multi-functional properties, stimuli responsiveness and enabled independent tuning of the stiffness and matrix stress relaxation rate to precisely tune the matrix for improved cellular functions. However, the synthesis of GelDT remained laborious and inefficient. Herein, we report a scalable, one-step synthesis of GelDT that enables precise control over dithiolane functionalization (3-97%) using a carbonate-bicarbonate buffer system under mild aqueous conditions, while reducing organic solvent consumption from liters to the milliliters scale and eliminating the use of reducing agents. GelDT hydrogels obtained using the new synthesis route exhibit high stability (weeks), tunable stiffness, shear thinning, and self-healing properties essential for minimally invasive delivery. Additionally, pre-gelation tuning
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