Evidence map›Paper›PMID 41816875›Full record

SynthesisJournal of sleep research2026

A Systematic Review on Insomnia and Circadian Rhythms Desynchronization in Obsessive-Compulsive Disorder: From Childhood to Adulthood.

Giovanna Grenno, Gaspare Alfì, Mario Miniati, Matteo Gambini, Andrea Coccoglioniti, Alessio A Gugliotta, Donatella Marazziti, Lino Nobili, Angelo Gemignani, Laura Palagini

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of sleep research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giovanna GrennoDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Gaspare AlfìDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.ORCID 0009-0000-6750-0040
Mario MiniatiDepartment of Neuroscience, University of Pisa Hospital, Pisa, Italy.
Matteo GambiniDepartment of Neuroscience, University of Pisa Hospital, Pisa, Italy.
Andrea CoccoglionitiDepartment of Neuroscience, University of Pisa Hospital, Pisa, Italy.
Alessio A GugliottaDepartment of Neuroscience, University of Padova, Padova, Italy.
Donatella MarazzitiDepartment of Neuroscience, University of Pisa Hospital, Pisa, Italy.
Lino NobiliDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Angelo GemignaniDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Laura PalaginiDepartment of Neuroscience, University of Pisa Hospital, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obsessive-compulsive disorder is frequently accompanied by sleep disturbances, particularly insomnia and circadian dysregulation. These conditions are increasingly recognised not only as comorbidities but also as factors potentially influencing the severity and course of obsessive-compulsive symptoms. This systematic review synthesises findings from 28 studies investigating the association between obsessive-compulsive disorder, insomnia and circadian alterations across different age groups. Insomnia was found to be highly prevalent among individuals with obsessive-compulsive disorder and associated with greater symptom severity, especially regarding intrusive thoughts and cognitive-affective dysregulation. Circadian disruptions, such as delayed sleep phase, evening chronotype, and atypical hormonal rhythms, were frequently observed and related to emotional instability and clinical variability. These results underscore the importance of systematically assessing and addressing sleep-related disturbances in patients with obsessive-compulsive disorder. Integrating sleep and circadian-focused strategies into clinical care may improve treatment outcomes and provide insight into underlying neurobiological mechanisms.

Indexed as

Circadian RhythmObsessive-Compulsive DisorderSleep Disorders, Circadian RhythmSleep Initiation and Maintenance DisordersAdolescentAdultChildChronotypeHumanschronotypecortisol rhythmdelayed sleep phaseemotional dysregulationmelatonin secretionsleep disturbances

Identifiers

PMID41816875
PMCPMC13357917

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.