Observational studyScience progress
Neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio combination for acute coronary syndrome risk stratification: A retrospective observational study from a Metropolitan Medical Center in Taiwan.
Observational study in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectiveTo evaluate the prognostic value of the combined neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) for adverse outcomes in Taiwanese patients with acute coronary syndrome (ACS).MethodsThis retrospective, single-center, observational cohort study analyzed 653 ACS patients from the Tri-Service General Hospital-coronary artery disease registry (Jan 2016-Aug 2018). NLR and MLR were calculated at presentation. The primary endpoint was a composite of in-hospital mortality and stroke. Optimal cut-off values were determined using receiver operating characteristic curve analysis (NLR > 5.22, MLR > 0.76). Univariable and multivariable logistic regression were used to assess the association of both elevated NLR/MLR with the primary endpoint.ResultsPatients with both elevated NLR and MLR (NLR > 5.22 and MLR > 0.76) demonstrated a significantly higher risk of the primary endpoint compared to the group with no elevation (OR = 7.16) in univariable analysis. This group also experienced longer hospital stays and higher non-cardiovascular mortality. However, this association became non-significant after multivariable adjustment for confounders.ConclusionsConcurrent elevation of both NLR and MLR at presentation is associated with increased in-hospital morbidity and prolonged hospitalization in ACS patients, although this did not remain an independent predictor in multivariable analysis. Ongoing statin therapy demonstrated a protective association in this cohort. These readily available markers may facilitate early risk stratification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.