Evidence map›Paper›PMID 41816736›Full record

ArticleTurkish journal of medical sciences2026

Preoperative inflammatory and molecular marker changes in 125 supratentorial glioma cases.

Semih Can Çetintaş, Burak Tahmazoğlu, Tufan Agah Kartum, Rahşan Kemerdere, Taner Tanriverdi

Abstract read
In one paragraph

Article in Turkish journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Semih Can ÇetintaşDepartment of Neurosurgery, Cerrahpaşa Medical Faculty, İstanbul University-Cerrahpaşa, İstanbul, Turkiye.ORCID https://orcid.org/0000-0001-6036-164X
Burak TahmazoğluDepartment of Neurosurgery, Cerrahpaşa Medical Faculty, İstanbul University-Cerrahpaşa, İstanbul, Turkiye.ORCID https://orcid.org/0000-0002-9248-9960
Tufan Agah KartumDepartment of Neurosurgery, Cerrahpaşa Medical Faculty, İstanbul University-Cerrahpaşa, İstanbul, Turkiye.ORCID https://orcid.org/0000-0003-1529-6476
Rahşan KemerdereDepartment of Neurosurgery, Cerrahpaşa Medical Faculty, İstanbul University-Cerrahpaşa, İstanbul, Turkiye.ORCID https://orcid.org/0000-0002-9947-3486
Taner TanriverdiDepartment of Neurosurgery, Cerrahpaşa Medical Faculty, İstanbul University-Cerrahpaşa, İstanbul, Turkiye.ORCID https://orcid.org/0000-0002-1878-0696

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/aim: To determine whether there is a possible link between selected preoperative systemic inflammatory markers and molecular pathological indices. Material and methods: For this retrospective study, 125 patients served as subjects. Preoperative systemic inflammatory markers, namely neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR), and postoperative pathological indices, namely mitosis, Ki-67 labeling index (LI), isocitrate dehydrogenase-1 (IDH1) mutation, and 1p/19q codeletion, were obtained from the electronic database. Results: Results showed that NLR positively correlated with PLR (p = 0.00001), mitotic activity (p = 0.001), and Ki-67 LI (p = 0.00001). On the other hand, LMR Conclusion: Our results suggest a link between systemic inflammation and histopathology, and higher NLR and/or lower LMR may be a novel prognostic marker in gliomas. A prospective multicenter study with a larger patient population would be more convincing. Until such a study is published, the results of retrospective studies, including ours, should be evaluated with caution.

Indexed as

Biomarkers, TumorGliomaInflammationSupratentorial NeoplasmsAdultAgedFemaleHumansIsocitrate DehydrogenaseMaleMiddle AgedMutationRetrospective StudiesYoung AdultBiomarkers, TumorIDH1 protein, humanIsocitrate Dehydrogenase1p/19q codeletionGliomasIDH1 mutationKi-67 labeling indexpreoperative systemic inflammatory marker

Identifiers

PMID41816736
PMCPMC12974312

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