ArticleJournal of biomedical optics2026
Label-free correlative morpho-chemical tomography of 3D kidney mesangial cells.
Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
9 authors.
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Abstract
Significance: Imaging 3D Aim: We aim to develop and demonstrate a correlative label-free imaging platform capable of simultaneously capturing morphological and chemical-specific information from 3D cultured kidney mesangial cells. Approach: We combined simultaneous label-free autofluorescence-multiharmonic (SLAM) microscopy and gradient light interference microscopy (GLIM) to extract both chemical-specific and morphological tomography of 3D cultured kidney mesangial cells. In this approach, SLAM provides a nonlinear imaging platform with a single excitation source to simultaneously acquire autofluorescence (FAD and NAD(P)H), second- and third-harmonic signals from the cells. Complementarily, GLIM acquires high-contrast quantitative phase information to quantify structural changes in samples with a thickness of up to Results: Our correlative imaging results demonstrate the ability to image and quantify both morphology and chemical-specific signals of kidney mesangial cells in 3D. The combination of GLIM and SLAM provides complementary information critical for understanding kidney function, including metabolism and matrix deposition under controlled physiological conditions. Conclusions: The proposed correlative imaging approach establishes a versatile and hassle-free platform for morpho-chemical cellular tomography, offering unique opportunities for studying the structure and function of 3D kidney models in their native state.
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