SynthesisFrontiers in medicine2026
Risk factors for acute kidney injury after coronary artery bypass graft surgery: a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Background: Acute kidney injury (AKI) is one of the common and severe complications following coronary artery bypass graft (CABG) surgery, significantly increasing patient mortality, complication rates, and length of hospital stay. Although numerous studies have explored risk factors for postoperative AKI after CABG, results remain inconsistent. This systematic review and meta-analysis aim to synthesize existing evidence to identify the primary risk factors for AKI following CABG. Methods: Systematically searched PubMed, Embase, Web of Science, and Cochrane Library databases from their inception to 20 September 2025. Observational studies reporting risk factors for postoperative AKI following CABG were included. Two researchers independently performed literature screening, data extraction, and quality assessment. Random-effects models were used to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs). The I Results: A total of 17 research papers involving 33,809 patients were included. The results of the meta-analysis suggest that older age [OR = 1.05, 95% CI (1.03, 1.08)], prolonged cardiopulmonary bypass [OR = 1.14, 95% CI (1.06, 1.22)], diabetes [OR = 1.29, 95% CI (1.15, 1.45)], intra-aortic balloon pump [OR = 3.19, 95% CI (1.74, 5.85)], transfusion of red blood cells [OR = 1.73, 95% CI (1.25, 2.38)] may be associated with the occurrence of AKI after CABG. Conclusion: Meta-analysis results indicate that older age, prolonged cardiopulmonary bypass duration, diabetes, intra-aortic balloon pump use, and red blood cell transfusion are all significant risk factors for AKI following CABG. Among these, prolonged cardiopulmonary bypass duration and intra-aortic balloon pump use exert a particularly pronounced effect on AKI occurrence. Systematic review registration: [https://www.crd.york.ac.uk/prospero/], identifier [CRD420251144655].
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