ArticleJournal of gastrointestinal oncology2026
Clinicopathological characteristics and prognosis of patients with mucinous adenocarcinoma originating from the left colon, right colon, or rectum: a nationwide retrospective study in China.
Article in Journal of gastrointestinal oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Young-onset signet ring cell colorectal adenocarcinoma: demographics, clinicopathological profile, and survival analysis.Proceedings (Baylor University. Medical Center) · 2026Article
- Prognostic impact of mucinous adenocarcinoma after curative surgery for stage I-III colorectal cancer: a large population-based cohort study.Journal of gastrointestinal oncology · 2026Article
- Clinical and pathological characteristics of mucinous adenocarcinoma in colon cancer: comparison with classic adenocarcinoma.BMC gastroenterology · 2026Article
- Anatomical Location Is Associated with Clinicopathological Features and Long-Term Oncological Outcomes in Mucinous Colorectal Adenocarcinoma: A Population-Based Analysis of 40,698 Patients from the SEER Database.Journal of clinical medicine · 2026Article
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Abstract
Background: The clinicopathological and prognostic features of colorectal cancer (CRC) originating from different locations differ greatly. However, the impact of tumour location on the clinicopathological features and prognosis of patients with colorectal mucinous adenocarcinoma (MAC) remains underexplored. This longitudinal international cohort study aimed to investigate the influence of tumour location on clinicopathological features, recurrence, and survival in patients with MAC. Methods: The clinicopathological data of CRC patients who underwent curative surgery and were pathologically diagnosed with MAC across 23 hospitals in China from 2016 to 2021 were collected. Data from 2016 to 2021 MAC patients in the Surveillance, Epidemiology, and End Results (SEER) database were also collected. The study was approved by the Institutional Review Board of The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital [approval No. YXLL-KY-2024(116)]. Chi-squared analysis, Fisher's exact test, or Kruskal-Wallis analysis of variance (ANOVA) was used to assess differences in categorical variables where appropriate. Kaplan-Meier curves were generated to assess survival, which was compared via log-rank tests. Univariable and multivariable survival analyses with Cox regression models were conducted to identify prognostic factors. Results: A total of 2,646 patients from the SEER cohort and 2,439 patients from the Chinese cohort met the eligibility criteria for inclusion in this study. In the SEER cohort, compared with the right-sided colon (RS) group and the left-sided colon (LS) group, the rectum (RC) group was significantly associated with aggressive histologic features, including a worse N (node) stage (P<0.001 and P=0.02) and tumour-node-metastasis (TNM) stage (P<0.001 and P=0.005). In the Chinese cohort, compared with the LS group, the RC group had a worse N stage (P<0.001) and TNM stage (P<0.001). And compared with the RS group, the LS group was significantly associated with aggressive histologic features. In the SEER cohort, the 3-year overall survival (OS) of patients in the RC group was significantly lower than that of patients in the RS group and the LS group (69.0% Conclusions: This nationwide multicentre retrospective study demonstrated that the clinicopathological features and prognoses of MAC patients differ between patients in Western countries and those in China. In addition, MACs originating from different tumour locations present divergent clinicopathological features and prognostic consequences. These findings provide new evidence for further exploration of the features of MAC, and the tumour location should receive increased attention in the clinical study and treatment of MAC.
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