Evidence map›Paper›PMID 41816551›Full record

ArticleFrontiers in dementia2026

From mild behavioral impairment-checklist (MBI-C) to MBI-distress (MBI-D): a paired assessment and clinical correlates of domain-specific caregiver distress in MCI due to AD.

Efthalia Angelopoulou, Niki Tsinia, Maria Hatzopoulou, Akylina Despoti, Vasiliki Kamtsadeli, Marina Papadogiani, Evangelia Stanitsa, Vasilis Kyriakidis, Sokratis Papageorgiou, John D Papatriantafyllou

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In one paragraph

Article in Frontiers in dementia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Efthalia Angelopoulou1st Department of Neurology, Aiginition University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Niki TsiniaThird Age Day Care Center IASIS, Athens, Greece.
Maria HatzopoulouThird Age Day Care Center IASIS, Athens, Greece.
Akylina DespotiThird Age Day Care Center IASIS, Athens, Greece.
Vasiliki KamtsadeliThird Age Day Care Center IASIS, Athens, Greece.
Marina PapadogianiThird Age Day Care Center IASIS, Athens, Greece.
Evangelia Stanitsa1st Department of Neurology, Aiginition University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Vasilis KyriakidisThird Age Day Care Center IASIS, Athens, Greece.
Sokratis Papageorgiou1st Department of Neurology, Aiginition University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
John D Papatriantafyllou1st Department of Neurology, Aiginition University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Mild behavioral impairment (MBI) captures later-life onset neuropsychiatric symptoms (NPS) that may herald neurodegeneration. The emotional impact of these early behavioral changes on caregivers is under-measured in pre-dementia care. Objective: To develop a brief, domain-aligned caregiver distress scale for MBI (MBI-D) and examine clinical correlates of MBI-related caregiver distress in mild cognitive impairment due to AD (MCI-AD). Methods: One hundred and four participant-informant dyads with MCI-AD at a Greek memory clinic were included. Caregivers completed the Greek MBI-C and the new five-item MBI-D (one item per ISTAART-AA MBI domain). Internal consistency (Cronbach's Results: Internal consistency of the MBI-D was moderate ( Conclusion: The MBI-D, strongly coupled with MBI-C, is a concise, clinically practical and scalable measure of MBI-related caregiver distress in MCI-AD, capturing both symptom burden and domain-specific distress in a single administration. Impulsivity, apathy, and affective dysregulation are highlighted as priority targets for early, caregiver-focused interventions advancing innovative, prevention-oriented dementia care delivery.

Indexed as

Alzheimer’s diseasecaregiver burdendementiamild behavioral impairmentmild behavioral impairment-checklistmild cognitive impairment

Identifiers

PMID41816551
PMCPMC12974401

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.