ArticleFrontiers in psychiatry2026
Layered vulnerabilities in young adults with major depressive disorder: personality, coping, and cognition.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Major depressive disorder (MDD) is a leading cause of disability worldwide, with peak incidence in young adulthood. Personality traits, coping styles, and cognitive functioning are established vulnerabilities, yet few studies have examined these dimensions together in young Asian adults. This study investigates whether personality, coping, and cognition function as layered vulnerabilities for MDD and whether their integration enhances diagnostic accuracy and identifies intervention targets, specifically in young Singaporean adults. Methods: In an exploratory case-control study, 36 patients with MDD and 36 matched healthy controls aged 21-29 years completed validated measures of personality traits, coping strategies, and cognition. Analyses included group comparisons, correlational analyses, and hierarchical regression models with false discovery rate correction. Results: Compared with controls, patients scored lower in emotional stability, conscientiousness, extraversion, and agreeableness; relied more on maladaptive coping; and reported more perceived cognitive deficits (all Conclusions: Personality, coping, and subjective cognition reflect layered vulnerabilities for MDD in young adults. Emotional stability emerged as the most impactful distal predictor, while perceived cognitive deficits provided a proximal, state-dependent marker, modestly enhancing diagnostic accuracy. Maladaptive coping related to symptom severity, highlighting its role as a potential intervention target. These findings illustrate how distal, semi-malleable, and proximal factors can inform early detection and targeted interventions.
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