ArticleStroke (Hoboken, N.J.)2026
Catheter-Based Focal Hypothermia With Endovascular Reperfusion in Acute Anterior Circulation Large Artery Occlusion Stroke (CHILL-ART): A Randomized Controlled Trial Protocol.
Article in Stroke (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06758609 (Local Hypothermia and Endovascular Recanalization for Acute Large Artery Occlusive Stroke-A Multicenter, Prospective, Open-label, Blinded-Endpoint, Randomized Controlled Trial), which is not on this map. Cited by 1 paper.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Local Hypothermia and Endovascular Recanalization for Acute Large Artery Occlusive Stroke-A Multicenter, Prospective, Open-label, Blinded-Endpoint, Randomized Controlled Trial
Who cites it
1 citing paper in PubMed.
- Beyond tumor biology: nursing interventions for psychological and immune health in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Review
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8 authors.
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Abstract
backgroundLarge vessel occlusion accounts for 28% to 46% of acute ischemic strokes, with mechanical thrombectomy (MT) demonstrating established efficacy. However, functional independence rates remain suboptimal, necessitating adjuvant neuroprotective strategies. Therapeutic hypothermia represents the most promising intervention among evaluated neuroprotective approaches. Our previous multicenter pilot trial indicated that catheter-based focal intracranial hypothermia exhibits a favorable safety profile and may confer prognostic benefits. However, this preliminary finding mandates rigorous validation. This trial aims to evaluate the efficacy and safety of catheter-based focal intracranial hypothermia combined with MT in patients with acute anterior circulation large artery occlusion.
methodsThe CHILL-ART (Catheter-Based Focal Intracranial Hypothermia Combined With Endovascular Reperfusion Therapy for Patients With Acute Anterior Circulation Large Artery Occlusion) is an investigator-initiated, multicenter, PROBE (Prospective Randomized Open-label Blinded End Point) trial. Twenty-six comprehensive stroke centers across China will enroll 262 eligible patients with occlusion of the internal carotid artery and the M1 segment of the middle cerebral artery within 24 hours of onset. Participants will be randomized 1:1 to receive either MT plus 350 mL of 4 °C saline (hypothermia group) or MT plus 350 mL of room-temperature (22-25 °C) saline (control group).
resultsThe primary outcome is the proportion of patients achieving a modified Rankin Scale score of 0 to 2 at 90 days. Secondary outcomes include excellent outcome (modified Rankin Scale score, 0-1), ordinal modified Rankin Scale shift analysis, reperfusion success rate (modified Thrombolysis in Cerebral Infarction [mTICI] score, 2b-3), infarct volume at 72 hours to 7 days, recurrent occlusion rate, rectal temperature, and early neurological deterioration. Safety end points comprise symptomatic intracranial hemorrhage within 72 hours, any intracranial hemorrhage, pneumonia, and urinary tract infections, cerebral herniation, coagulation disorders, bradycardia, electrolyte disturbances, vasospasm, deep vein thrombosis, and 90-day mortality.
conclusionsThe CHILL-ART trial will provide evidence of the efficacy and safety of catheter-based focal intracranial hypothermia as adjuvant therapy combined with MT for patients with acute anterior circulation large artery occlusion. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT06758609.
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