ArticleAlzheimer's & dementia (New York, N. Y.)
Sex differences in blood pressure hemodynamics and white matter hyperintensity volume across racial ethnic groups-HABS-HD.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionIt remains unclear whether specific blood pressure components-systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), or mean arterial pressure (MAP)-are similarly associated with white matter hyperintensity (WMH) burden across sexes within racial and ethnic groups.
methodsParticipants were drawn from the Health and Aging Brain Study-Health Disparities (HABS-HD) and included non-Hispanic White (NHW;
resultsAmong NHW participants, higher SBP and PP were more strongly associated with greater WMH volume in females compared to males. Among NHB participants, blood pressure-WMH associations did not differ by sex. Among Hispanic participants, females exhibited greater WMH volume in DBP- and MAP-adjusted models, although blood pressure-WMH associations were stronger in males. DISCUSSION: Blood pressure-WMH associations differ by sex within racial and ethnic groups. These findings highlight intersectional heterogeneity in cerebrovascular vulnerability and suggest that sex-specific blood pressure-related pathways to small-vessel injury vary across racial and ethnic contexts. Highlights: Non-Hispanic White (NHW) females showed stronger systolic blood pressure (SBP)- and pulse pressure (PP)-white matter hyperintensity (WMH) associations than NHW males.Blood pressure (BP)-WMH associations did not differ by sex among non-Hispanic Black participants.Among Hispanic adults, BP-WMH associations were stronger in males than females.Antihypertensive use was associated with higher WMHs across race and ethnic groups.BP-related WMH vulnerability varies by sex and race and ethnic context.
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