ReviewFrontiers in cellular and infection microbiology2026
Gut microbiota and macrophage crosstalk: implications for colitis-associated colorectal cancer.
Review in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Fermented Durian Tempoyak as a Source of Probiotics for Colorectal Cancer Prevention through Gut Microbiome Modulation.Current gastroenterology reports · 2026Review
- Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colitis-associated colorectal cancer (CAC) is one of the most severe complications associated with inflammatory bowel disease (IBD). Within the global landscape of cancer epidemiology, colorectal cancer (CRC) ranks among the leading malignancies in terms of both incidence and mortality. CAC, which arises in the context of IBD-including Crohn's disease and ulcerative colitis-represents a distinct subtype of CRC that is closely linked to chronic intestinal inflammation. The pathogenesis of CAC is driven by the complex intestinal microenvironment, characterized by dynamic interactions among immune cells, epithelial cells, and the gut microbiota. In this setting, macrophages serve as central regulators of intestinal immunity and exhibit significant plasticity in response to microbial stimuli. Under homeostatic conditions, macrophages contribute to tissue integrity through phagocytic activity and the production of anti-inflammatory mediators. However, during prolonged inflammation, persistent exposure to a dysbiotic microbiota induces functional reprogramming of macrophages toward a pro-tumorigenic phenotype. Pathogenic bacteria enriched in CAC tissues-such as
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