ReviewFrontiers in immunology2026
Neutrophil and macrophage zonation in liver disease: from spatiotemporal dynamics to advanced computational analysis.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Spatial immune niche remodeling of the neutrophil-macrophage axis inchronic liver disease.Frontiers in cell and developmental biology · 2026Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver disease progression is profoundly shaped by the spatial and temporal dynamics of innate immune cells, particularly neutrophils and macrophages. Recent advances in single-cell and spatial omics, intravital imaging, and multiplexed histology have revealed how these cells exhibit distinct zonation patterns along the portal-central axis and undergo dynamic reprogramming in response to injury, infection, and metabolic stress. Neutrophils preferentially accumulate in necrotic or pericentral zones, whereas macrophage subsets adopt diverse zonal identities and display remarkable plasticity, collectively orchestrating inflammation and tissue repair. In this review, we consolidate current knowledge on neutrophil and macrophage zonation in liver disease, emphasizing their roles in shaping pathophysiology and clinical outcomes. We also briefly outline how emerging technologies are refining our understanding of immune microanatomy and may pave the way for precision hepatology.
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