Evidence map›Paper›PMID 41816282›Full record

ArticleiScience2026

Sexual dimorphism of early GPR183-dependent B cell responses in systemic lupus erythematosus.

Diana E Matei, Nina M de Gruijter, Persephone Jenkins, Anna Radziszewska, Hannah Peckham, Bethany Jebson, Kersti Karu, Coziana Ciurtin, Elizabeth C Rosser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Diana E MateiCentre for Adolescent Rheumatology at University College London, University College London and Great Ormond Street Hospitals, London, UK.
Nina M de GruijterCentre for Adolescent Rheumatology at University College London, University College London and Great Ormond Street Hospitals, London, UK.
Persephone JenkinsCentre for Adolescent Rheumatology at University College London, University College London and Great Ormond Street Hospitals, London, UK.
Anna RadziszewskaCentre for Adolescent Rheumatology at University College London, University College London and Great Ormond Street Hospitals, London, UK.
Hannah PeckhamCentre for Adolescent Rheumatology at University College London, University College London and Great Ormond Street Hospitals, London, UK.
Bethany JebsonCentre for Adolescent Rheumatology at University College London, University College London and Great Ormond Street Hospitals, London, UK.
Kersti KaruUCL Chemistry Mass Spectrometry Facility, Department of Chemistry, University College London, London, UK.
Coziana CiurtinCentre for Adolescent Rheumatology at University College London, University College London and Great Ormond Street Hospitals, London, UK.
Elizabeth C RosserCentre for Adolescent Rheumatology at University College London, University College London and Great Ormond Street Hospitals, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sensing oxidized cholesterol (oxysterol) ligands by GPR183-expressing B cells spatially regulates B cell activation within secondary lymphoid tissues, which, when dysregulated, could contribute to B cell-driven autoimmunity. Here, we show that in systemic lupus erythematosus, GPR183-expressing B cells are reduced in both humans and mice with established disease, irrespective of sex. However, we further show that GPR183-expressing splenic B cells are increased during the initiation phase of lupus-like disease in female but not male mice, leading to sex differences in the ability of B cells to migrate toward GPR183's principal ligand 7α,25dihydroxycholesterol

Indexed as

Biological sciencesimmunology

Identifiers

PMID41816282
PMCPMC12972708

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.