Evidence map›Paper›PMID 41816222›Full record

ArticleCase reports in radiology2026

Subacute Combined Degeneration Secondary to Nitrous Oxide Toxicity.

George Hanna, Panagiotis Gavathas, Jerome Hanna, Mina Mousa

Abstract read
In one paragraph

Article in Case reports in radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

George HannaDepartment of Radiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA, uthscsa.edu.ORCID https://orcid.org/0009-0004-1189-7121
Panagiotis GavathasDepartment of Radiation Oncology, Loma Linda University Medical Center, Loma Linda, California, USA, lomalindahealth.org.ORCID https://orcid.org/0009-0000-9938-2632
Jerome HannaDepartment of Anesthesiology, The University of Texas at Tyler, Tyler, Texas, USA, uttyler.edu.ORCID https://orcid.org/0009-0001-0269-3483
Mina MousaTallahassee Memorial Healthcare INC, Radiology Associates of Tallahassee, Tallahassee, Florida, USA.ORCID https://orcid.org/0000-0001-8619-9740

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subacute combined degeneration (SCD) of the spinal cord is a neurological condition caused by vitamin B12 deficiency and is most associated with cases of malabsorption, nitrous oxide exposure, or pernicious anemia. The lateral corticospinal tracts and dorsal columns are classically affected, leading to neurologic symptoms including gait disturbance, sensory deficits, and weakness. We report the case of a 35-year-old man who presented with paraesthesia and weakness of the upper and lower extremities bilaterally, along with urinary incontinence. Examination revealed a long segment of signal abnormality and enhancement involving the cervical and thoracic spinal cord, predominantly along the bilateral dorsal column. Upon further investigation, the patient reported a chronic history of recreational nitrous oxide abuse resulting in vitamin B12 deficiency inevitably leading to the development of SCD of the spinal cord.

Indexed as

nitrous oxidesubacute combined degenerationvitamin B12 deficiency

Identifiers

PMID41816222
PMCPMC12974326

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.