cAMP/PKA signaling in endocrine hypertension: genetic mechanisms and pathophysiological insights.

Jose Antonio B Lima Sobrinho, Madson Q Almeida

Abstract readReview

In one paragraph

Review in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jose Antonio B Lima SobrinhoUnidade de Adrenal, Laboratório de Endocrinologia Molecular e Celular Laboratório de Investigação Médica 25' (LIM25), Divisão de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Madson Q AlmeidaUnidade de Adrenal, Laboratório de Endocrinologia Molecular e Celular Laboratório de Investigação Médica 25' (LIM25), Divisão de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling pathway plays a central role in adrenal function, steroidogenesis, and blood pressure regulation. Increasing evidence suggests that dysregulation of this pathway contributes to several forms of hypertension, both endocrine and non-endocrine. A growing number of germline and somatic alterations affecting components of the cAMP/PKA axis have been implicated as key drivers of hypertensive disorders. Among these, activating pathogenic variants (PV) in

Indexed as

Cyclic AMPCyclic AMP-Dependent Protein KinasesHypertensionSignal TransductionAnimalsChromograninsGTP-Binding Protein alpha Subunits, GsHumansChromograninsCyclic AMPCyclic AMP-Dependent Protein KinasesGTP-Binding Protein alpha Subunits, GscAMPCushing syndromeendocrine hypertensionphosphodiesteraseprimary aldosteronismprotein kinase A

Identifiers

PMID41816209

DOI10.3389/fendo.2026.1748702

PMCPMC12971441

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.