Evidence map›Paper›PMID 41816196›Full record

ArticleAlzheimer's & dementia. Behavior & socioeconomics of aging2026

Association of residential neighborhood disadvantage with amyloid PET positivity among cognitively impaired individuals.

Charles C Windon, Elena Tsoy, Jennifer Livaudais-Toman, Torsten B Neilands, Nynikka R Palmer, Margo B Heston, Julene K Johnson, Lucy Hanna, Constantine Gatsonis, Justin Romanoff and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia. Behavior & socioeconomics of aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Charles C WindonDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0001-8719-1206
Elena TsoyDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Jennifer Livaudais-TomanDepartment of Medicine, Division of General Internal Medicine, University of California, San Francisco, San Francisco, California, USA.
Torsten B NeilandsCenter for Aging in Diverse Communities, University of California, San Francisco, San Francisco, California, USA.
Nynikka R PalmerCenter for Aging in Diverse Communities, University of California, San Francisco, San Francisco, California, USA.
Margo B HestonDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Julene K JohnsonCenter for Aging in Diverse Communities, University of California, San Francisco, San Francisco, California, USA.
Lucy HannaCenter for Statistical Sciences, Brown University School of Public Health, Providence, Rhode Island, USA.
Constantine GatsonisCenter for Statistical Sciences, Brown University School of Public Health, Providence, Rhode Island, USA.
Justin RomanoffCenter for Statistical Sciences, Brown University School of Public Health, Providence, Rhode Island, USA.
Jon SteingrimssonCenter for Statistical Sciences, Brown University School of Public Health, Providence, Rhode Island, USA.
Maria C CarrilloAlzheimer's Association, Chicago, Illinois, USA.
Peggye Dilworth-AndersonHealth Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Bruce E HillnerDepartment of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Barry A SiegelEdward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Rachel A WhitmerDivision of Research, Kaiser Permanente, Pleasanton, California, USA.
Consuelo H WilkinsDepartment of Medicine, Division of Geriatric Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Karen SmithDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Ganna BlazhenetsDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Renaud La JoieDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Bruce L MillerDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Katherine L PossinDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Gil D RabinoviciDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.

Funding

RESOURCE CENTER FOR AGING RESEARCH IN DIVERSE POPULATIONP30AG015272 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Torsten Brian Neilands · 1997 to 2026
$19.5M
Augmenting Nurse Support and EHR Integration for the Pragmatic Trial of the UCSF-BHAU01NS128913 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine Laurel Possin · 2022 to 2026
$8.2M
Reimagining Precision Medicine Approaches to AD DiagnosisR35AG072362 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POSSIN, KATHERINE LAUREL, RABINOVICI, GIL DAN · 2021 to 2025
$4.8M
Amyloid PET and Blood-Based Biomarkers of AD among Diverse PopulationsK23AG093166 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Charles Christian Windon · 2025 to 2026
$328k
The Disadvantage Exposome as a Driver of Alzheimer’s Disease PathologyK00AG097172 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Margo Heston · 2025 to 2026
$169k
NIA NIH HHS K00 AG097172NIA NIH HHS K23 AG093166NIA NIH HHS P30 AG015272NIA NIH HHS R35 AG072362NINDS NIH HHS U01 NS128913
6 · The paper itself

Abstract

introductionRelationships between Alzheimer's disease neuropathology, residential neighborhood, and cognitive impairment remain incompletely understood.

methodsWe examined whether residence within a disadvantaged neighborhood was associated with amyloid positron emission tomography (PET) positivity. We used data from the observational, multisite, Imaging Dementia-Evidence for Amyloid Scanning study that included cognitively impaired Medicare beneficiaries. Our secondary analysis examined multivariable-adjusted associations between neighborhood disadvantage (measured by Area Deprivation Index [ADI] deciles 1-90 vs. 91-100 representing greatest disadvantage) and amyloid PET positivity.

resultsAmong 15,346 White, 829 Latino, 637 Black/African American, and 321 Asian individuals, 51% were female, mean age was 75.7 years, 535 (3.8%) resided in ADI 91 to 100 decile, and 61.6% were amyloid PET positive. The ADI 91-100 decile was associated with lower odds of PET positivity by visual interpretation (odds ratio [OR] 0.80, 95% confidence interval [CI] 0.67-0.96,

conclusionResidence in the most disadvantaged neighborhoods may be associated with lower amyloid pathology in cognitively impaired individuals.

Indexed as

Alzheimer’s diseaseamyloid positron emission tomographydementiaethnicityMedicaremild cognitive impairment

Identifiers

PMID41816196
PMCPMC12973527

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.