Trial reportDrug design, development and therapy2026
Effect of Preoperative Esketamine Nebulized Inhalation on Cough Reflex, Sedation, and Postoperative Sore Throat in Extubation of Surgical Patients: A Prospective, Double-Blind, Randomized Controlled Trial.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Preoperative Stellate Ganglion Block for Postoperative Sore Throat in Patients Undergoing Double-Lumen Endotracheal Intubation: A Randomized Clinical Trial.Drug design, development and therapy · 2026Trial
- Prophylactic esketamine for postoperative sore throat: a meta-analysis of randomized evidence.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Observational study on the application of different esketamine gargle doses for the prevention of postoperative sore throat after laryngeal mask airway insertion.Frontiers in pharmacology · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aims to explore the effect of preoperative esketamine nebulized inhalation on cough reflex during extubation for surgical patients who received general anesthesia. Patients and methods: A total of 84 patients scheduled for thoracolumbar spine surgery were included in the study. All patients were randomly divided into two groups. Patients in the experimental group (Group K) received 5 mL of esketamine solution (50 mg esketamine + 3 mL of saline) by nebulized inhalation for 15 minutes. Patients in the control group (Group S) received an equal volume of saline as placebo. The incidence and intensity of the cough reflex were evaluated. The Riker Sedation-Agitation Scale score, Ramsay sedation score, and Monitoring of sore throat following surgery were performed at 0, 2, 4, 6, 12, and 24 hours post-surgery. Results: The incidence of cough reflex was lower in Group K (31.0%) than in Group S (71.4%), and cough intensity was milder in Group K than in Group S ( Conclusion: Preoperative esketamine nebulized inhalation has a potential inhibitory effect on the cough reflex during extubation for patients who received general anesthesia via tracheal intubation.
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