ArticleQuantitative imaging in medicine and surgery2026
Automated segmentation and quantitative analysis of vascular curvature features in unruptured intracranial aneurysms based on time-of-flight magnetic resonance angiography (TOF-MRA).
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Arterial tortuosity is closely related to the formation, progression, and rupture of unruptured intracranial aneurysms (UIAs). This study aimed to assess the relationship between 3-dimensional (3D) centerline curvatures and the UIA formation risk, at the level of the entire cerebral arterial trunks and the parent arteries of UIAs in different hemodynamic locations. Methods: This retrospective study evaluated the association between 3D centerline curvatures and the risk of UIAs in a cohort of 101 patients (114 aneurysms) and 145 healthy controls (HC) enrolled between March 2020 and February 2023. Tortuosity index (TI) and 3D centerline curvatures of 9 major cerebral arteries were automatically extracted from magnetic resonance angiography (MRA). Curvature parameters of cerebral arterial trunks were compared between UIA patients and HC and analyzed for their association with UIA formation. Additionally, curvature parameters of the parent arteries were compared with their contralateral counterparts in both sidewall and bifurcation aneurysms. Results: Compared to HC, UIA patients exhibited significantly higher curvature parameters (P<0.001), whereas TI showed no significant difference. Increased curvature parameters are strongly correlated with a higher UIA risk [odds ratio (OR) ranging from 2.69 to 10.62]. In parent artery analysis, sidewall aneurysms demonstrated elevated curvature parameters versus contralateral arteries, including total absolute curvature (P=0.049), average absolute curvature (P=0.023), root-mean-square curvature (P =0.014), standard deviation of curvature (P=0.014), and 90% maximum absolute curvature (P=0.008), whereas bifurcation aneurysms showed no differences. Conclusions: Increased 3D centerline curvatures of cerebral arteries significantly correlate with higher UIA risk, particularly in sidewall aneurysms. Assessing 3D centerline curvatures provides valuable insights into aneurysm hemodynamics and supports a comprehensive assessment of aneurysm risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.