ArticleQuantitative imaging in medicine and surgery2026
Comparison of the normalized cerebral blood volume (CBV) between different models and evaluation of the efficacy of gadolinium leakage in evaluating preoperative adult-type gliomas.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) can be used to differentiate the glioma grade and characterize the high-perfusion cores of gliomas. However, the arterial input function (AIF) and gamma-variate fitting (GVF) can both derive perfusion metrics [e.g., the relative cerebral blood volume (rCBV)]. The study aimed to compare the consistency of the normalized rCBV (nrCBV) between AIF and GVF in adult-type gliomas with different grades and isocitrate dehydrogenase (IDH) statuses, and then investigated the efficiency of percentage of signal recovery (PSR) and gadolinium (Gd) leakage effects in evaluating adult-type gliomas. Methods: A total of 60 patients with preoperative adult-type gliomas [IDH-mutant (IDH Results: AIF-nrCBV was correlated with GVF-nrCBV in adult-type gliomas with different grades and IDH statuses (r=0.56-0.90, all P<0.01). However, the AIF slightly underestimated the nrCBV compared with the GVF in adult-type gliomas with grade 2 (-0.09±0.27) and IDH Conclusions: AIF-nrCBV is correlated with the GVF-nrCBV in adult-type gliomas, regardless of grades and IDH statuses; however, the grades and IDH statuses could affect the consistency of the nrCBV between AIF and GVF. The T
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