ArticleQuantitative imaging in medicine and surgery2026
A multimodal ultrasound approach: quantitative speed-of-sound, elastography, and B-mode imaging for predicting papillary thyroid carcinoma invasiveness.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Papillary thyroid carcinoma (PTC) is the most common malignant tumor of the thyroid gland, and its aggressiveness determines distinct therapeutic and management strategies. This study aimed to evaluate the diagnostic performance of quantitative speed-of-sound (QSOS), elastography, and B-mode imaging in assessing the aggressiveness of PTC. Methods: A total of 157 patients with solitary PTC were enrolled and classified into two groups based on pathological findings: an invasive group (n=118) and a non-invasive group (n=39). All patients underwent B-mode imaging, QSOS imaging, and elastography. Speed-of-sound (SOS)1, SOS2, and SOS3 represent the SOS measurements at different regions of the nodule, and the difference refers to the value of SOS1 minus SOS3. Results: Our results demonstrated that the maximum diameter of PTC in the invasive group was significantly larger than that in the non-invasive group {9.5 [interquartile range (IQR), 7.1-12.3] Conclusions: Our study is the first to examine the invasiveness of PTC using QSOS technology. To predict PTC invasiveness, a combined predictor integrating SOS, elastography, and B-mode imaging parameters of thyroid nodules was developed. This indicator provides physicians with valuable guidance for the early diagnosis and treatment of PTC due to its excellent accuracy, sensitivity, and specificity.
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