ArticleFrontiers in transplantation2026
Double whammy: increased severe primary graft dysfunction after prolonged warm ischemia and inadequate oxygen delivery during heart transplant.
Article in Frontiers in transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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19 authors.
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Abstract
Objective: This exploratory study examined the relationship between oxygen delivery index (DO2i) during DCD heart transplant (HT), warm ischemic time, and posttransplant outcomes. Methods: All DCD HT between 10/2021 and 12/2024 using normothermic regional perfusion ( Results: The critical area under 260 mL/min/m2 was the best predictor of severe primary graft dysfunction (PGD). 102 patients met inclusion criteria, and were stratified into four groups based on FWIT above/below 23 min and critical area below/above 1,424 mL/m2 (identified by ROC analysis). 39 (38.2%) patients had low FWIT/ high DO2i, 18 (17.6%) had low FWIT/ low DO2i, 24 (23.5%) had high FWIT/high DO2i, and 21 (20.6%) had high FWIT/low DO2i. Rates of severe PGD were greater in the high FWIT/low DO2i group compared to the low FWIT/high DO2i group (23.8% vs. 0%, Conclusions: Higher oxygen delivery during HT was associated with improved short-term outcomes, and may counteract the myocardial damage from warm ischemia during DCD.
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