Evidence map›Paper›PMID 41816018›Full record

ReviewEuropean heart journal. Imaging methods and practice2026

Artificial intelligence-based characterization of multi-organ ultrasound congestion across the heart failure Spectrum.

Lavinia Del Punta, Giacomo Aru, Alina Sirbu, Nicolò De Biase, Stefano Taddei, Giuseppe Prencipe, Stefano Masi, Nicola Riccardo Pugliese

Abstract readReview
In one paragraph

Review in European heart journal. Imaging methods and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lavinia Del PuntaDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, Pisa 56124, Italy.
Giacomo AruComputer Science Department, University of Pisa, Largo Bruno Pontecorvo 3, Pisa, Italy.
Alina SirbuDepartment of Computer Science and Engineering, University of Bologna, Via Mura Anteo Zamboni 7, Bologna 40126, Italy.
Nicolò De BiaseDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, Pisa 56124, Italy.
Stefano TaddeiDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, Pisa 56124, Italy.
Giuseppe PrencipeDepartment of Computer Science and Engineering, University of Bologna, Via Mura Anteo Zamboni 7, Bologna 40126, Italy.
Stefano MasiDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, Pisa 56124, Italy.
Nicola Riccardo PuglieseDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, Pisa 56124, Italy.ORCID https://orcid.org/0000-0002-5473-227X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: To investigate, using artificial intelligence (AI), the relationships between ultrasound (US)-defined systemic congestion and demographic, echocardiographic, and biohumoral parameters across the heart failure (HF) spectrum. Methods and results: A total of 1588 subjects (651 Stage A-B, 376 HF with reduced left ventricular ejection fraction [HFrEF, <50%], and 561 HF with preserved ejection fraction [HFpEF, ≥50%]) underwent comprehensive clinical evaluation, laboratory testing, echocardiography, and US assessment of congestion, including inferior vena cava (IVC), lung ultrasound (LUS), renal venous flow (RVF), portal venous flow (PVF), and hepatic venous flow (HVF). Assessment of IVC, LUS, and RVF was available in the entire cohort, whereas HVF and PVF were performed in 359 and 289 patients, respectively. Overall, 856 patients had no US signs of congestion, 458 had one US sign, and 274 had ≥2 US signs (multi-organ congestion). AI-based predictive models were developed for each site of congestion and for multi-organ congestion using a 3-item model (IVC, LUS, RVF). Congestion-related features clustered into four domains: medical history, biohumoral variables, left heart morphology and function, and right heart and pulmonary circulation. The 3-item model identified mitral annular systolic velocity, systolic and diastolic pulmonary artery pressure, triglycerides, left atrial volume index, diabetes, and treatment with furosemide or angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers as key predictors of multi-organ congestion (area under the curve = 0.79). Conclusion: AI-assisted integration of multi-organ US characterizes congestion as a multidimensional phenotype beyond conventional clinical assessment and biomarkers across the HF spectrum.

Indexed as

artificial intelligenceheart failure spectrummulti-organ ultrasoundultrasound-defined congestion

Identifiers

PMID41816018
PMCPMC12975183

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.