Evidence map›Paper›PMID 41815983›Full record

ArticleResearch and practice in thrombosis and haemostasis2026

Persons with high Hemophilia Joint Health Scores have reduced functional range of motion during simulated sports activities.

Danielle N Siegel, Caden Robertson, Joanna Roybal, Joseph Mah, Laura Singer-Fox, Dianne Thornhill, Niamh Mah, Sharon Funk, Marilyn Manco-Johnson, James Carollo and 2 more

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In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Danielle N SiegelHemophilia and Thrombosis Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Caden RobertsonHemophilia and Thrombosis Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Joanna RoybalHemophilia and Thrombosis Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Joseph MahHemophilia and Thrombosis Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Laura Singer-FoxHemophilia and Thrombosis Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Dianne ThornhillHemophilia and Thrombosis Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Niamh MahHemophilia and Thrombosis Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Sharon FunkHemophilia and Thrombosis Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Marilyn Manco-JohnsonHemophilia and Thrombosis Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
James CarolloThe Center for Gait and Movement Analysis, Children's Hospital Colorado, Aurora, Colorado, USA.
Brecca M M GaffneyDepartment of Mechanical Engineering, University of Colorado Denver, Denver, Colorado, USA.
Beth B WarrenHemophilia and Thrombosis Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Funding

Exploring the Biomechanics of Joint Bleeding in Persons with Hemophilia to BetterK23HL151886 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI WARREN, BETH BOULDEN · 2021 to 2025
$912k
NHLBI NIH HHS K23 HL151886
6 · The paper itself

Abstract

Background: Joint bleeds for persons with hemophilia are characteristic and can lead to hemophilic arthropathy, primarily in the ankles, knees, and elbows. The Hemophilia Joint Health Score (HJHS) is a validated physical exam measure of hemophilic arthropathy but does not take into account functional range of motion (ROM). Objectives: To examine the association between HJHS severity and functional ROM during simulated sports activities in persons with hemophilia compared with healthy controls. Methods: Using motion capture analysis, functional ROM at the ankle, knee, and hip was measured in 86 persons with hemophilia A or B and 33 healthy controls while performing 10 simulated sports activities. Comparisons of functional ROM were made across 5 groups (1 control and 4 hemophilia groups based on total 6-joint HJHS) using Jonckheere-Terpstra and Kolmogorov-Smirnov post hoc analyses. Results: Persons with hemophilia who had a total 6-joint HJHS ≥25 demonstrated reduced functional ROM compared with controls, most notably at the ankle, where significant reductions were observed in 8 of 10 activities. Persons with hemophilia who had a total 6-joint HJHS <25 showed functional ROM similar to controls, with no significant reductions in any joint during any activity. Conclusion: Decreased functional ROM in persons with hemophilia, with a 6-joint HJHS ≥25, represents a threshold for significantly diminished movement capacity. Further understanding the relationship between HJHS and functional ROM can support earlier identification of mobility limitations, inform targeted rehabilitation, and guide interventions to preserve activity in persons with hemophilia.

Indexed as

hemophiliaHJHSmotion capturerange of motionROM

Identifiers

PMID41815983
PMCPMC12974100

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.