ArticleThe World Allergy Organization journal2026
Sleep disturbances and psychological factors as mediators between gastrointestinal symptoms and disease severity in chronic spontaneous urticaria.
Article in The World Allergy Organization journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Dysregulation of gastrointestinal function has been implicated in the pathogenesis of chronic spontaneous urticaria (CSU). Moreover, persistent wheals and pruritus in CSU are frequently accompanied by sleep disturbances and psychological distress. However, whether sleep quality and psychological factors mediate the association between gastrointestinal symptoms and CSU disease severity remains unclear. Methods: This study retrospectively analyzed data from 499 CSU patients. Associations between CSU disease activity and gastrointestinal symptoms, sleep quality, and psychological status were assessed. Mediation analyses were conducted to evaluate whether sleep quality and psychological status mediated the relationship between gastrointestinal symptoms and disease activity. Results: Gastrointestinal symptoms were significantly associated with CSU disease activity. Multivariate analysis identified gastrointestinal symptoms as an independent risk factor for increased CSU disease activity (adjusted OR = 1.85, 95% CI: 1.23-2.78). Among individual gastrointestinal symptoms, diarrhea and abdominal pain showed the strongest correlations. Mediation analyses revealed partial mediation by psychological factors, with sleep disturbance (13.17%), anxiety (17.28%), and stress (21.09%) accounting for significant proportions of the total effect. Conclusion: Gastrointestinal symptoms are independently associated with increased CSU disease activity. This relationship is partially mediated by sleep disturbances, anxiety, and stress, highlighting the relevance of the gut-brain-skin axis in CSU management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.