Evidence map›Paper›PMID 41815946›Full record

ArticleGMS hygiene and infection control2026

Acute mastoiditis caused by Klebsiella pneumoniae carbapenemase (KPC) producing bacteria - an atypical cause.

Aristos Aristodimou, Zacharias Raptopoulos, Georgios Georgiou, Elena Xenofontos, Loukia Dramiotou

Abstract readCase Reports
In one paragraph

Article in GMS hygiene and infection control, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aristos AristodimouInternal Medicine Department, Limassol General Hospital, State Health Organization Services, Limassol, Cyprus.
Zacharias RaptopoulosInternal Medicine Department, Limassol General Hospital, State Health Organization Services, Limassol, Cyprus.
Georgios GeorgiouEar - Nose - Throat (ENT) Department, Limassol General Hospital, State Health Organization Services, Limassol, Cyprus.
Elena XenofontosInternal Medicine Department, Limassol General Hospital, State Health Organization Services, Limassol, Cyprus.
Loukia DramiotouInternal Medicine Department, Limassol General Hospital, State Health Organization Services, Limassol, Cyprus.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: The aim of this report is to present a rare case of acute mastoiditis caused by Methods: The following report describes a 78-year-old immunosuppressed female who was hospitalized due to left-sided acute otitis media complicated by tympanic membrane rupture and acute mastoiditis. Fluid-discharge culture revealed KPC. The patient successfully received four weeks of conservative treatment with intravenous colistin (based on antibiotic susceptibilities). Discussion: Acute mastoiditis is a rare complication of acute otitis media, mostly seen in pediatric populations. The most frequent causative agents identified are Gram-positive cocci such as Conclusion: The incidence of infection by KPC is rising, especially in immunosuppressed patients and those with recent and/or prolonged hospitalizations. There are very few reports in the literature describing acute mastoiditis caused by KPC. Infection with KPC not only has a high 30-day mortality rate (up to 40%) but also poses a significant financial burden on the healthcare system.

Indexed as

acute mastoiditiscarbapenemase producing Klebsiella pneumoniaeimmunosuppressionKPC

Identifiers

PMID41815946
PMCPMC12973384

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.