Evidence map›Paper›PMID 41815926›Full record

ArticleRevista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia2026

Doppler signal analysis of the tricuspid valve in healthy fetuses during the first trimester: a cohort study.

Gustavo Fonseca de Albuquerque Souza, Cínthia Freire Carvalho, Adricia Cristine Souza Alves, Laura Mendes Rodrigues, Renato Barros Moraes, Alex Sandro Rolland Souza

Abstract read
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In one paragraph

Article in Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gustavo Fonseca de Albuquerque SouzaInstituto de Medicina Integral Prof. Fernando Figueira Centro de Atenção à Mulher RecifePE Brazil Centro de Atenção à Mulher, Instituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, Brazil.ORCID https://orcid.org/0000-0002-1794-701X
Cínthia Freire CarvalhoInstituto de Medicina Integral Prof. Fernando Figueira Centro de Atenção à Mulher RecifePE Brazil Centro de Atenção à Mulher, Instituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, Brazil.ORCID https://orcid.org/0000-0002-6170-7750
Adricia Cristine Souza AlvesUniversidade Católica de Pernambuco Escola de Saúde e Ciências da Vida RecifePE Brazil Escola de Saúde e Ciências da Vida, Universidade Católica de Pernambuco, Recife, PE, Brazil.ORCID https://orcid.org/0000-0001-9043-394X
Laura Mendes RodriguesUniversidade Católica de Pernambuco Escola de Saúde e Ciências da Vida RecifePE Brazil Escola de Saúde e Ciências da Vida, Universidade Católica de Pernambuco, Recife, PE, Brazil.ORCID https://orcid.org/0000-0002-1258-7836
Renato Barros MoraesUniversidade Católica de Pernambuco Escola de Saúde e Ciências da Vida RecifePE Brazil Escola de Saúde e Ciências da Vida, Universidade Católica de Pernambuco, Recife, PE, Brazil.ORCID https://orcid.org/0000-0002-9513-5260
Alex Sandro Rolland SouzaInstituto de Medicina Integral Prof. Fernando Figueira Centro de Atenção à Mulher RecifePE Brazil Centro de Atenção à Mulher, Instituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, Brazil.ORCID https://orcid.org/0000-0001-7039-2052

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to characterize tricuspid valve sound signals in healthy fetuses during the first trimester of pregnancy using Doppler ultrasound and computational analysis. Methods: A cohort of pregnant women at 11-14 weeks of normal-risk gestation was assessed at the Results: Early diastolic (E) wave presented a mean duration of 70.89±9.26 ms, with ApEn 0.25±0.15, LZC 0.77±0.15, and DFA 0.73. Atrial contraction (A) wave had 79.77±7.56 ms, ApEn 0.25±0.15, LZC 0.77±0.19, and DFA 0.52. Systole showed 225.95±15.88 ms, ApEn 0.15±0.17, LZC 0.78±0.15, and DFA 0.75. Diastole had 150.66±13.99 ms, ApEn 0.18±0.11, LZC 0.83±0.22, and DFA 0.66. The full cardiac cycle lasted 376.61±16.40 ms, with ApEn 0.18±0.11, LZC 0.83±0.22, and DFA 0.81. The diastole/cardiac cycle ratio was 0.4±0.3, with ApEn 0.22±0.12, LZC 0.72±0.15, and DFA 0.62. Conclusion: This study offers a detailed characterization of tricuspid valve wave segments in healthy fetuses during early gestation. The integration of linear and non-linear analyses may enhance our understanding of fetal cardiac physiology. Further research is needed to evaluate whether these parameters can assist in the early detection of congenital heart diseases. We highlight the potential of these parameters for early screening of congenital heart disease and chromosomal abnormalities, while emphasizing the need for further studies to confirm their diagnostic value.

Indexed as

Echocardiography, DopplerFetal HeartTricuspid ValveUltrasonography, DopplerUltrasonography, PrenatalAdultCohort StudiesFemaleHumansPregnancyPregnancy Trimester, FirstDoppler ultrasoundFetal heartPregnancy trimester, firstPrenatal diagnosisTricuspid valve

Identifiers

PMID41815926
PMCPMC12975111

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.