Evidence map›Paper›PMID 41815853›Full record

Trial reportJournal of medicine and life2026

A proprietary herbal extract of ashwagandha root for stress and anxiety in healthy adults: a randomized, double-blind, three-arm, placebo-controlled efficacy and safety study.

Rogene Eichler West, Anima Biswas, Rahul Rao, Himanshu Tayade, John Ademola

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of medicine and life, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rogene Eichler WestNeuroscience, Northwest Neuro Professionals, LLC, Seattle, United States of America.
Anima BiswasObstetrics and gynaecology, Clini-Ton-Multi-Speciality Clinic, Jaipur, India.
Rahul RaoDentistry, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, India.
Himanshu TayadePharmcology, D Y Patil University School of Medicine, Pune, India.
John AdemolaClinical Research, San Francisco Research Institute, San Francisco , United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress and anxiety are interconnected, sharing both behavioural and neural foundations. Ashwagandha (

Indexed as

AnxietyPlant ExtractsPlant RootsStress, PsychologicalWithaniaAdolescentAdultAgedDouble-Blind MethodFemaleHumansHydrocortisoneMaleMiddle AgedYoung AdultAshwagandhaHydrocortisonePlant ExtractsALP, Alkaline phosphataseALT, Alanine transaminaseANOVA, Analysis of varianceanxietyAPB, Proprietary herbal extract of ashwagandha rootARE, Ashwagandha root extractAST, Aspartate transaminaseBDNF, Brain-derived neurotrophic factorBRIEF-A, Behavior Rating Inventory of Executive Function–Adult VersionBUN, Blood urea nitrogenCBT, Cognitive behavioral therapycGMP, Current good manufacturing practicesCOMPASS, Computerised Mental Performance Assessment SystemCONSORT, Consolidated Standards of Reporting TrialscortisolCTRI, Clinical Trials Registry of IndiaELISA, Enzyme-linked immunosorbent assayERA, Esteem-related affectGAD, Generalized Anxiety DisorderGCP, Good Clinical PracticeGSH, Glutathione peroxidaseHAM-A, Hamilton Anxiety Rating ScaleHPA, Hypothalamic–pituitary–adrenalHPG, Hypothalamic–pituitary–gonadalITT, Intention-to-treatLFT, Liver function testsMDA, MalondialdehydeMFS, Mental Fatigue ScaleOHQ, Oxford Happiness Questionnaireperceived stress scalePL, PlaceboPOMS, Profile of Mood StatesPP, Per-protocolproprietary herbal extract of ashwagandhaPSS-10, Perceived Stress Scale–10PTSD, Post-traumatic stress disorderRFT, Renal function testsSAEs, Serious adverse eventsSD, Standard deviationSMD, Standardized mean differenceSOD, Superoxide dismutasestressTEAEs, Treatment-emergent adverse eventsTESAEs, Treatment-emergent serious adverse eventsTMD, Total mood disturbanceWithania somnifera

Identifiers

PMID41815853
PMCPMC12973907

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.