Evidence map›Paper›PMID 41815767›Full record

ArticleJCPP advances2026

Why do attention-deficit/hyperactive disorder and/or autism traits place adolescents at risk for depression? Protocol for a longitudinal comparison of the mediating role of emotion regulation deficits versus emotional burden.

Edmund J S Sonuga-Barke, Melanie Palmer, Kirsty Griffiths, Anna Wyatt, Andrea Danese, Susie Chandler, Daniel Stahl, Steve Lukito, Georgia Pavlopoulou, Emily Simonoff and 1 more

Abstract read
In one paragraph

Article in JCPP advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Edmund J S Sonuga-BarkeDepartment of Child & Adolescent Psychiatry Institute of Psychiatry, Psychology & Neuroscience King's College London London UK.ORCID https://orcid.org/0000-0002-6996-3935
Melanie PalmerUniversity College London London UK.
Kirsty GriffithsDepartment of Child & Adolescent Psychiatry Institute of Psychiatry, Psychology & Neuroscience King's College London London UK.
Anna WyattDepartment of Child & Adolescent Psychiatry Institute of Psychiatry, Psychology & Neuroscience King's College London London UK.
Andrea DaneseDepartment of Child & Adolescent Psychiatry Institute of Psychiatry, Psychology & Neuroscience King's College London London UK.ORCID https://orcid.org/0000-0001-8718-5412
Susie ChandlerDepartment of Child & Adolescent Psychiatry Institute of Psychiatry, Psychology & Neuroscience King's College London London UK.ORCID https://orcid.org/0000-0002-5543-8638
Daniel StahlDepartment of Biostatistics and Health Informatics Institute of Psychiatry Psychology & Neuroscience King's College London London UK.
Steve LukitoDepartment of Child & Adolescent Psychiatry Institute of Psychiatry, Psychology & Neuroscience King's College London London UK.
Georgia PavlopoulouUniversity College London London UK.
Emily SimonoffDepartment of Child & Adolescent Psychiatry Institute of Psychiatry, Psychology & Neuroscience King's College London London UK.
RE‐STAR team

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Depression levels increase dramatically during adolescence in the general population. This effect is exacerbated in adolescents with a diagnosis of attention-deficit/hyperactivity disorder (ADHD), autism, or both. Here we detail the protocol for the Methods: A sample of 600 adolescents aged 11-16 years, enriched for the presence of autism and ADHD diagnosed cases, and their parent/guardian will be recruited via schools, local NHS (South London and Maudsley) and ADHD and autism charities. Measures of ADHD, autism and depression, ERD, EB, self-esteem, rumination, resilience and alexithymia will be completed at baseline, 6 months and/or 12 months by parents and/or participants. Background factors such as age, sex, cognitive abilities and socioeconomic status as well as service use and medication status will also be collected. Results: The pathways between ADHD/autism and depression, along with their mediators and moderators, will be analysed using structural equation modelling. Conclusion: The findings from MEMO will feed into the other studies within the RE-STAR programme to support the development of an intervention to reduce ADHD and/or autism-related depression risk in adolescence.

Indexed as

ADHDadolescenceautismlongitudinalmental healthschools

Identifiers

PMID41815767
PMCPMC12973166

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.