Evidence map›Paper›PMID 41815641›Full record

ArticleOpen life sciences2026

Curcumin induces apoptosis in osteosarcoma cells by regulating the glycolytic pathway via the MAPK axis: a mechanistic study.

Yi Wang, Yuxi Zhang, Yuhan Zhang, Jierui Zhao, Jinlian Liao, Jingwen Luo, Min Chen, Peng Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yi WangFaculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, Macau SAR, 999078, China.
Yuxi ZhangThe Islands Healthcare Complex - Macao Medical Center of Peking Union Medical College Hospital, Macao, Macao SAR, 999078, China.
Yuhan ZhangChangchun University of Chinese Medicine, Changchun, Jilin 130012, China.
Jierui ZhaoFaculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, Macau SAR, 999078, China.
Jinlian LiaoFaculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, Macau SAR, 999078, China.
Jingwen LuoFaculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, Macau SAR, 999078, China.
Min ChenFaculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, Macau SAR, 999078, China.
Peng PengThe Islands Healthcare Complex - Macao Medical Center of Peking Union Medical College Hospital, Macao, Macao SAR, 999078, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the mechanism by which curcumin induces apoptosis through glycolytic regulation in osteosarcoma cells (U2OS, MG63) via the MAPK axis. Network pharmacology, protein-protein interaction analysis, and molecular docking were integrated to identify core targets and validate the central role of the MAPK pathway.

Indexed as

apoptosiscurcuminglycolysisosteosarcoma cellsP38/JNK

Identifiers

PMID41815641
PMCPMC12974748

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.