Evidence map›Paper›PMID 41815635›Full record

ArticleAging brain2026

Plasma neurofilament light is associated with hippocampal volume and memory performance but not functional connectivity in older adults with and without mild cognitive decline.

Youjin Jung, Scott E Counts, Benjamin M Hampstead, Scott J Peltier, Henry L Paulson, Bruno Giordani, Arijit K Bhaumik, John S Beck, Jessica S Damoiseaux

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Article in Aging brain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Youjin JungDepartment of Psychology, Wayne State University, Detroit, MI 48202, USA.
Scott E CountsDepartments of Translational Neuroscience and Family Medicine, Michigan State University, Grand Rapids, MI 49503, USA.
Benjamin M HampsteadMichigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.
Scott J PeltierFunctional MRI Laboratory, University of Michigan, Ann Arbor, MI 48109, USA.
Henry L PaulsonMichigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.
Bruno GiordaniMichigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.
Arijit K BhaumikMichigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.
John S BeckDepartments of Translational Neuroscience and Family Medicine, Michigan State University, Grand Rapids, MI 49503, USA.
Jessica S DamoiseauxDepartment of Psychology, Wayne State University, Detroit, MI 48202, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasma neurofilament light chains (pNfL) have shown promise as a biomarker for tracking and predicting neurodegeneration, such as cortical atrophy and hypometabolism, in Alzheimer's Disease (AD). However, it is still not clear whether neurofilament light chains (NfL) also reflect alterations in the functional connectivity (FC) of the default mode network (DMN), a functional network showing alterations in earlier stages of AD. In this cross-sectional study including 62 cognitively unimpaired (CU) and 47 cognitively impaired (CI) older adults likely due to AD, we measured FC in the posterior midline DMN, and its FC with frontal DMN, temporoparietal DMN, and hippocampus. We also examined whether the previously observed relationships between pNfL and hippocampal volume, as well as memory function, are replicated in our dataset. pNfL showed no association with DMN FC in either the CI or the CU group. However, higher pNfL was associated with lower right hippocampal volume and memory score in the CI group. Our results support the utility of pNfL as a biomarker tracking hippocampal atrophy and memory function but not for predicting DMN FC in older adults with cognitive decline of Alzheimer's type.

Indexed as

Default mode networkFunctional connectivityHippocampusMemoryNeurofilament light

Identifiers

PMID41815635
PMCPMC12972998

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.