Evidence map›Paper›PMID 41815630›Full record

ArticleCureus2026

A Silicone-Based Film-Forming Gel Wound Dressing for Radiation Dermatitis in Head and Neck Cancer Patients: A Retrospective Cohort Analysis Using Clinical Informatics.

Eulanca Y Liu, Erika Jank, P Travis Courtney, Jesus Juarez, Ting Martin Ma, William Delery, Lydia Chau, Vishruth Reddy, Myung Shin Sim, Robert K Chin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. MASCC oncodermatology clinical practice statement: prevention of acute radiation dermatitis using barrier-forming topical agents.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eulanca Y LiuRadiation Oncology, University of California Los Angeles, Los Angeles, USA.
Erika JankRadiation Oncology, Physics and Biology in Medicine, University of California Los Angeles, Los Angeles, USA.
P Travis CourtneyRadiation Oncology, University of California Los Angeles, Los Angeles, USA.
Jesus JuarezRadiation Oncology, University of California Los Angeles, Los Angeles, USA.
Ting Martin MaRadiation Oncology, University of Washington, Seattle, USA.
William DeleryRadiation Oncology, Neurological Surgery, University of California Los Angeles, Los Angeles, USA.
Lydia ChauRadiation Oncology, University of California Los Angeles, Los Angeles, USA.
Vishruth ReddyRadiation Oncology, University of California Los Angeles, Los Angeles, USA.
Myung Shin SimGeneral Internal Medicine and Health Services Research, University of California Los Angeles, Los Angeles, USA.
Robert K ChinRadiation Oncology, University of California Los Angeles, Los Angeles, USA.
Ricky R SavjaniRadiation Oncology, University of California Los Angeles, Los Angeles, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose Patients undergoing radiotherapy for head and neck cancers often experience radiation dermatitis, which is typically managed by applying topical moisturizers. A silicone-based polymer film with antibacterial properties, StrataXRT, has been developed to mitigate radiation-induced side effects. We sought to determine the efficacy of StrataXRT compared with standard moisturizers in reducing the incidence of severe radiation dermatitis in patients with head and neck malignancies. Materials and methods We conducted a retrospective analysis of patients treated with StrataXRT compared with historical controls using conventional moisturizers (largely Aquaphor®) via a clinical informatics approach. Propensity score matching was used to control for dosimetric properties: mean skin dose, maximum skin dose, and the surface area receiving 40 Gy or higher. The endpoint was grade 2+ radiation dermatitis, measured using Common Terminology Criteria for Adverse Events or CTCAE, in 171 patients treated with StrataXRT, compared with 171 matched patients treated with a standard moisturizer. Multivariable Cox regression was performed to estimate the association between StrataXRT and standard moisturizer while adjusting for confounding clinical variables. Results In the multivariable Cox regression, the hazard ratio was 0.61 (95% CI (0.37, 1.0), p=0.049) with a relative reduction in the risk of grade 2+ radiation dermatitis of 36.5% with the use of StrataXRT compared with standard moisturizers. The absolute risk reduction with StrataXRT was 14.5%, which translates to a number needed to treat of seven patients to prevent one occurrence of grade 2+ radiation dermatitis. Conclusions Patients benefited from StrataXRT, with a significant reduction in the incidence of grade 2+ radiation dermatitis throughout the course of treatment. This study supports the adoption of a novel topical agent providing barrier protection in the form of a film-forming gel to reduce acute radiation dermatitis in head and neck cancer patients.

Indexed as

desquamationfilm-forming gelhead and neck cancer (h&n cancer)radiation dermatitisretrospective clinical trial

Identifiers

PMID41815630
PMCPMC12973108

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.