ArticleCureus2026
Exploring Patterns of Palmar Hyperlinearity in Pediatric Population With Atopic Dermatitis or Ichthyosis Vulgaris Attending a Tertiary Care Hospital in Jaipur, India.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionIchthyosis vulgaris (IV) and atopic dermatitis (AD) are skin diseases occurring in children and having important quality-of-life implications. Palmar hyperlinearity has been characterized as a visible sign of skin barrier abnormality in these disorders.
methodsIn this hospital-based cross-sectional study, children aged six months to 18 years with a confirmed diagnosis of AD, IV, or both were assessed for five pre-defined palmar patterns. Patterns were graded as hyperlinear or non-hyperlinear, and their correlation with disease groups was examined. Inter-rater reliability was evaluated in a subset.
resultsOut of the 206 recruited participants, 121 children (58.7%) had hyperlinear patterns. Frequent cross-hatch was the most common hyperlinear pattern overall, found in relation to isolated AD predominantly. Thick perpendicular lines were most prevalent in IV-only cases, and frequent diamond patterns occurred in children with both AD and IV. Classification was found to have considerable inter-observer agreement (Fleiss Kappa statistic= 0.62).
conclusionsPatterns of palmar hyperlinearity in AD and IV are different. Detection can be a low-cost adjunct for the early diagnosis and phenotyping, particularly in cases where genetic analysis is not accessible.
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