ArticleFrontiers in neuroscience2026
Correlation between brain symmetry index and motor function in Parkinson's disease: a cross-sectional study.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Parkinson's disease (PD) present with asymmetric motor impairments in the different stages. The study aims to explore the pair-wise derived brain symmetry index (pdBSI) of electroencephalography (EEG) for the stage in PD. Materials and methods: 96 early Stage (ePD), 85 advanced Stage (aPD) and 67 healthy individuals were recruited. EEG and MDS-UPDRS Scale were applied to the study. pdBSI of EEG was calculated and divided into the frontal, the central and the posterior regions. Results: The PD Group exhibited significant differences in pdBSI across the full-frequency band in the whole-brain, especially in the central region. The PD groups showed higher levels of Conclusion: There were hemispheric asymmetry in the PD patients. The pdBSI was a potential electrophysiological biomarker for hemispheric asymmetry in the PD. β2-pdBSI in the central and posterior region was significantly associated with the severity of gait impairment in aPD patients. In addition, the stage-dependent gradient elucidates the dynamic shift from unilateral to bilateral network involvement. Our findings underscore that quantifying interhemispheric asymmetry, beyond examining power in isolated regions, provides unique insights into the pathophysiology and clinical progression of PD.
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