Evidence map›Paper›PMID 41815463›Full record

ArticleInternational journal of surgery case reports2026

A pediatric nasopharyngeal carcinoma masquerading as Kimura disease: a rare case report from Nepal.

Sagar Mandal, Anuj Pant, Abhishek Kumar Shah, Shankar Paudel, Bishal Panthi, Bipashwi Ratna Shakya

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Article in International journal of surgery case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Sagar MandalTribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.ORCID https://orcid.org/0009-0001-7854-3465
Anuj PantTribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.
Abhishek Kumar ShahTribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.
Shankar PaudelTribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.
Bishal PanthiTribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.
Bipashwi Ratna ShakyaDepartment of ENT - Head & Neck Surgery (ENT-HNS), Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction and Importance: Nasopharyngeal carcinoma (NPC) is an epithelial malignancy of the nasopharyngeal mucosa, most often arising in the fossa of Rosenmüller. While exceedingly rare in children under 10 years, it shows a male predominance. Case presentation: A 9-year-old male presented with bilateral cervical lymphadenopathy persisting for 1 year. Initially, unilateral right-sided neck swelling progressed to bilateral involvement with a left-sided mass. Trucut biopsy showed features consistent with Kimura disease. Repeat ultrasound-guided lymph node biopsy revealed an Epstein-Barr virus (EBV)-positive non-keratinizing metastatic carcinoma, suggestive of NPC, further confirmed by immunohistochemical analysis. Treatment with neoadjuvant platinum-based chemotherapy, followed by radiotherapy, achieved a complete clinical response at 6 months. Clinical Discussion: This case demonstrates a critical diagnostic pitfall where pediatric NPC initially masqueraded as Kimura disease due to inflammatory-predominant tissue sampling. The diagnostic breakthrough came through repeat ultrasound-guided biopsy with comprehensive immunohistochemical analysis and EBV-encoded RNA Conclusion: In a resource-limited setting like Nepal, for the early diagnosis and treatment of NPC, a combination of novel testing methods and a high index of suspicion in a patient with unilateral or bilateral neck swelling is necessary.

Indexed as

cisplatinEBV positivefine needle aspiration biopsyKimura diseasenasopharyngeal carcinoma

Identifiers

PMID41815463
PMCPMC12974392

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