Evidence map›Paper›PMID 41815401›Full record

ArticleRSC advances2026

New isoxazole-based heterocyclic hybrids with dual antimicrobial and antioxidant bioactivity: integrated synthesis,

Aziz Arzine, Soumia Ait Assou, Lamiae El Bouamri, Mohammed Chalkha, Asmae Nakkabi, Samir Chtita, Reem M Aljowaie, Mourad A M Aboul-Soud, Mohammed El Hassouni, John P Giesy and 1 more

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aziz ArzineEngineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences Dhar EL Mahraz, Sidi Mohamed Ben Abdellah University P.O. Box 1796 (Atlas) 30000 Fez Morocco arzineaziz@gmail.com mohammed.chalkha1@usmba.ac.ma.
Soumia Ait AssouBiotechnology, Environment, Agri-Food and Health Laboratory, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University BP. 1796, Atlas Fez Morocco.
Lamiae El BouamriLaboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca Casablanca B.P 7955 Morocco.ORCID https://orcid.org/0009-0004-7637-7928
Mohammed ChalkhaEngineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences Dhar EL Mahraz, Sidi Mohamed Ben Abdellah University P.O. Box 1796 (Atlas) 30000 Fez Morocco arzineaziz@gmail.com mohammed.chalkha1@usmba.ac.ma.ORCID https://orcid.org/0000-0002-9400-2183
Asmae NakkabiEngineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences Dhar EL Mahraz, Sidi Mohamed Ben Abdellah University P.O. Box 1796 (Atlas) 30000 Fez Morocco arzineaziz@gmail.com mohammed.chalkha1@usmba.ac.ma.
Samir ChtitaLaboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca Casablanca B.P 7955 Morocco.ORCID https://orcid.org/0000-0003-2344-5101
Reem M AljowaieDepartment of Botany and Microbiology, College of Science, King Saud University P.O. Box 2455 Riyadh 11451 Saudi Arabia.
Mourad A M Aboul-SoudCenter of Excellence in Biotechnology Research, College of Applied Medical Sciences, King Saud University Riyadh 11433 Saudi Arabia maboulsoud@ksu.edu.sa.ORCID https://orcid.org/0000-0001-9395-0563
Mohammed El HassouniBiotechnology, Environment, Agri-Food and Health Laboratory, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University BP. 1796, Atlas Fez Morocco.ORCID https://orcid.org/0000-0002-6741-4799
John P GiesyDepartment of Veterinary Biomedical Sciences, Toxicology Centre, Western College of Veterinary Medicine, University of Saskatchewan Saskatoon SK S7N 5B4 Canada.ORCID https://orcid.org/0000-0003-1931-9962
Mohamed El YazidiEngineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences Dhar EL Mahraz, Sidi Mohamed Ben Abdellah University P.O. Box 1796 (Atlas) 30000 Fez Morocco arzineaziz@gmail.com mohammed.chalkha1@usmba.ac.ma.ORCID https://orcid.org/0000-0002-2772-6632

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, novel isoxazole-based hybrid compounds 5a-h were synthesized with satisfactory yields. Their structure was confirmed by FT-IR, NMR (

Identifiers

PMID41815401
PMCPMC12973378

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.