Exploration of the association of antidiabetic drugs with urolithiasis: A drug-targeted Mendelian randomization study.

Xidong Wang, Qiancheng Mao, Tianqi Wang, Yingying Yang, Ming Liu, Jitao Wu

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Article in Asian journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Xidong WangDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.

Qiancheng MaoDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.

Tianqi WangDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.

Yingying YangDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.

Ming LiuDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.

Jitao WuDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Type 2 diabetes mellitus has previously been reported to be potentially associated with urolithiasis. We conducted a Mendelian randomization (MR) study to explore whether there is a causal relationship between genetic susceptibility to common antidiabetic drugs and urolithiasis risk. Methods: We used genetic variants from two different sources as instruments to proxy the exposure to antidiabetic drugs for our MR research design. The variants included loci regulating expression traits of the target genes, and genetic variants associated with blood glucose nearby or within antidiabetic drug target genes from genome-wide association studies. We ultimately calculated estimates using inverse-variance weighted MR (IVW-MR) and summary-data-based MR methods. Results: The Bonferroni-corrected IVW results suggested potassium inwardly rectifying channel subfamily J member 11 ( Conclusion: This study provided evidence for a potential causal link between

Indexed as

Antidiabetic drugsSummary-data-based Mendelian randomizationType 2 diabetes mellitusUrolithiasis

Identifiers

PMID41815369

DOI10.1016/j.ajur.2025.03.012

PMCPMC12974191

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.