Evidence map›Paper›PMID 41815349›Full record

ArticleBioactive materials2026

Copper phosphate nanozymes combat implant-related infections by inducing cuproptosis-like death and inhibiting the two-component system.

Yaxin Liu, Yang Zheng, Dasheng Tian, Yiwei Sun, Min Wang, Sihai Li, Erxu Tao, Yujing Liao, Fei Huang, Tao Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yaxin LiuDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, PR China.
Yang ZhengResearch Center of Nanomedicine Technology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530000, PR China.
Dasheng TianDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, PR China.
Yiwei SunDepartment of Orthopedics, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, PR China.
Min WangSchool of Biomedical Engineering, Anhui Medical University, Hefei, 230032, PR China.
Sihai LiDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, PR China.
Erxu TaoDepartment of Orthopedics, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, PR China.
Yujing LiaoResearch Center of Nanomedicine Technology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530000, PR China.
Fei HuangDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, PR China.
Tao WangDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, PR China.
Xianwen WangDepartment of Plastic and Reconstructive Surgery, Research Center for Translational Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implant-related infections, characterized by recalcitrant biofilm formation, antibiotic resistance, and immune evasion, pose a severe clinical burden in orthopedics due to the limited therapeutic efficacy of conventional approaches. Addressing this challenge requires innovative strategies capable of simultaneously disrupting biofilms and overcoming bacterial defense mechanisms. To address this, we developed flower-like copper phosphate (CuP) nanozymes with dual enzymatic activities (peroxidase- and glutathione peroxidase-like) that synergistically eradicate biofilms for implant-related infections through cuproptosis-like death and two-component system (TCS) inhibition.

Indexed as

Bacterial biofilmCuproptosis-like deathImplant-related infectionNanozymesTwo-component system

Identifiers

PMID41815349
PMCPMC12972616

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.