ArticleStroke (Hoboken, N.J.)2026
Visual Tools for Informed Decision-Making in Large-Core Thrombectomy for Acute Ischemic Stroke.
Article in Stroke (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent randomized clinical trials have demonstrated that endovascular thrombectomy (EVT) improves outcomes in patients with large ischemic cores. Despite these findings, hyperacute decision-making in large-core acute ischemic stroke remains challenging, as patients continue to face high rates of disability and mortality. Clear communication of risks and benefits is essential, and visual aids may improve comprehension in emergency settings.
methodsNinety-day modified Rankin Scale score distributions were pooled from 6 large-core thrombectomy trials: RESCUE-Japan LIMIT (Recovery by Endovascular Salvage for Cerebral Ultra-Acute Embolism-Japan Large Ischemic Core Trial), SELECT-2 (Randomized Controlled Trial to Optimize Patient's Selection for Endovascular Treatment in Acute Ischemic Stroke), ANGEL-ASPECT (Study of Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients With a Large Infarct Core), TENSION (Efficacy and Safety of Thrombectomy in Stroke With Extended Lesion and Extended Time Window), TESLA (Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke), and LASTE (Large Stroke Therapy Evaluation). Outcomes included functional independence (modified Rankin Scale score, 0-2), acceptable outcome (modified Rankin Scale score, 0-3), symptomatic intracranial hemorrhage, and decompressive hemicraniectomy. Benefit per hundred and harm per hundred were calculated by comparing EVT with medical management. Net benefit was defined as benefit per hundred minus harm per hundred. Visual decision aids, including a Single Personograph Choice Consequence Matrix, were developed to illustrate the pooled results.
resultsAcross 1872 patients, EVT increased rates of functional independence (19.5% versus 7.5%) and acceptable outcomes (36.5% versus 20.0%) compared with medical management. EVT also reduced severe disability (12.2% versus 20.6%) and mortality (31.0% versus 37.2%). Rates of symptomatic intracranial hemorrhage were 5.5% in the EVT arm and 3.2% in the medical management arm, while hemicraniectomy occurred in 12.1% and 10.4%, respectively, corresponding to an excess harm of 3.9%. The calculated benefit per hundred ranged from 16.5% (modified Rankin Scale score, 0-2) to 55.6% (ordinal shift), with an average of 36.1%. The visual aid illustrated that when scaled to a cohort of 100 patients receiving EVT, 40 would be expected to benefit, 4 to experience harm, 31 to die, and 29 to show no difference compared with medical management.
conclusionsEVT for large-core acute ischemic stroke provides substantial benefit despite increased risks of hemorrhage and surgical rescue. Visual decision aids based on pooled trial data offer an objective method for presenting outcomes, supporting informed and timely decision-making in acute stroke care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.