Evidence map›Paper›PMID 41815302›Full record

ArticleStroke (Hoboken, N.J.)2026

Effect of Acute Intracranial Stenting in Patients With Successful Reperfusion Following Large-Vessel Occlusion Secondary to Intracranial Atherosclerosis: Secondary Analyses of the RESCUE-ICAS Study.

Sarah Nguyen, Adam de Havenon, Eyad Almallouhi, Mohammad A Jumaa, Violiza Inoa, Francesco Capasso, Michael I Nahhas, Robert M Starke, Isabel Fragata, Matthew T Bender and 35 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05403593 (Registry of Emergent Large VeSsel OCclUsion DuE to IntraCranial AtherosclerosiS), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05403593 completednot on this map

Registry of Emergent Large VeSsel OCclUsion DuE to IntraCranial AtherosclerosiS

Typeobservational_patient_registrySponsorMedical University of South CarolinaRan2021 to 2024Enrolled600ConditionsIntracranial Stenosis, Large Vessel Occlusion, Mechanical ThrombectomyArmsNo Intervention
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

Sarah NguyenDepartment of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City (S.N., R.G.).ORCID https://orcid.org/0000-0002-2985-1517
Adam de HavenonDepartment of Neurology, Boston Medical Center, Boston University School of Medicine, MA (A.H., T.N.N.).ORCID https://orcid.org/0000-0001-8178-8597
Eyad AlmallouhiNeurointerventional Surgery, Sarasota Memorial Hospital, FL (E.A.).ORCID https://orcid.org/0000-0002-6873-7901
Mohammad A JumaaDepartment of Neurology, University of Toledo College of Medicine and Life Sciences, OH (M.A.J., A.M., S.F.Z.).ORCID https://orcid.org/0000-0002-7165-797X
Violiza InoaDepartment of Neurology, Semmes Murphey Clinic, University of Tennessee Health Science Center, Memphis (V.I., N.G.).ORCID https://orcid.org/0000-0003-0399-3346
Francesco CapassoInterventional Neuroradiology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy (F.C.).ORCID https://orcid.org/0000-0003-1087-6092
Michael I NahhasDepartment of Neurology, University of Texas Health, Houston (M.I.N.).ORCID https://orcid.org/0000-0001-8198-7676
Robert M StarkeDepartment of Neurosurgery, University of Miami, FL (R.M.S.).
Isabel FragataDepartment of Neuroradiology, Hospital São José, Unidade Local de Saúde, Lisbon, Portugal (I.F.).
Matthew T BenderDepartment of Neurosurgery, University of Rochester Medical Center, NY (M.T.B.).
Krisztina MoldovanDepartment of Neurology, Warren Alpert Medical School of Brown University, Providence, RI (K.M., S.Y.).
Shadi YaghiDepartment of Neurology, Warren Alpert Medical School of Brown University, Providence, RI (K.M., S.Y.).ORCID https://orcid.org/0000-0003-0031-1004
IlkoL MaierDepartment of Neurology, University Medicine Göttingen, Germany (I.L.M.).ORCID https://orcid.org/0000-0001-6988-8878
Jonathan A GrossbergDepartment of Neurosurgery, Emory University, Atlanta, Georgia (J.A.G., A.M.A.).ORCID https://orcid.org/0000-0002-1152-8826
Pascal M JabbourDepartment of Neurosurgery, Thomas Jefferson University, Philadelphia, PA (P.M.J., S.I.T.).ORCID https://orcid.org/0000-0002-8965-2413
Marios-Nikos PsychogiosDepartment of Neuroradiology, Clinic of Radiology and Nuclear Medicine, University Hospital Basel, Switzerland (M.-N.P.).ORCID https://orcid.org/0000-0002-0016-414X
Edgar A SamaniegoDepartment of Neurology, University of Iowa Hospitals and Clinics, Iowa City (E.A.S.).ORCID https://orcid.org/0000-0003-2764-2268
Jan-Karl BurkhardtDepartment of Neurosurgery, University of Pennsylvania, Philadelphia (J.-K.B.).ORCID https://orcid.org/0000-0001-8381-0313
Brian T JankowitzDepartment of Neurosurgery, Hackensack Meridian Neuroscience Institute, JFK University Medical Center, Edison, NJ (B.T.J.).ORCID https://orcid.org/0000-0001-9306-0763
Mohamad AbdalkaderDepartment of Radiology, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, MA (M. Abdalkader).ORCID https://orcid.org/0000-0002-9528-301X
Ameer E HassanDepartment of Neuroscience, Valley Baptist Medical Center, Harlingen, TX (A.E.H.).ORCID https://orcid.org/0000-0002-7148-7616
David J AltschulDepartment of Neurosurgery and Montefiore-Einstein Cerebrovascular Research Lab, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY (D.J.A.).ORCID https://orcid.org/0000-0002-5130-1378
Justin MascitelliDepartment of Neurosurgery, University of Texas Health and Science Center, San Antonio (J.M.).
Robert W RegenhardtNeuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston (R.W.R.).ORCID https://orcid.org/0000-0003-2958-3484
Stacey Q WolfeDepartment of Neurological Surgery, Wake Forest School of Medicine, Winston-Salem, NC (S.Q.W.).ORCID https://orcid.org/0000-0001-7603-2728
Mohamad EzzeldinNeuroendovascular Surgery, HCA Houston Healthcare Kingwood, TX (M.E.).ORCID https://orcid.org/0000-0001-7740-8774
Kaustubh LimayeDepartment of Neurology, Indiana University, Bloomington (K.L.).ORCID https://orcid.org/0000-0002-7280-7407
Hosam Al-JehaniDepartment of Neurosurgery, King Fahad Hospital of the University, Alkhobar, Saudi Arabia (H.A.-J.).ORCID https://orcid.org/0000-0002-3830-9789
Hafeez NiaziDepartment of Neurology, Wellspan Health, York, PA (H.N.).
Nitin GoyalDepartment of Neurology, Semmes Murphey Clinic, University of Tennessee Health Science Center, Memphis (V.I., N.G.).ORCID https://orcid.org/0000-0002-4699-0922
Stavropoula I TjoumakarisDepartment of Neurosurgery, Thomas Jefferson University, Philadelphia, PA (P.M.J., S.I.T.).ORCID https://orcid.org/0000-0002-1054-9414
Ali M AlawiehDepartment of Neurosurgery, Emory University, Atlanta, Georgia (J.A.G., A.M.A.).ORCID https://orcid.org/0000-0003-2601-8850
Mohammed AlmekhlafiDepartments of Clinical Neurosciences, Radiology, and Community Health Sciences, Hotchkiss Brain Institute and O'Brien Institute for Public Health, Cumming School of Medicine at the University of Calgary, AB, Canada (M. Almekhlafi).ORCID https://orcid.org/0000-0001-9550-8197
Eytan RazDepartment of Neurosurgery and Radiology, NYU Langone Health, New York (E.R.).ORCID https://orcid.org/0000-0003-2998-8481
Adam MierzwaDepartment of Neurology, University of Toledo College of Medicine and Life Sciences, OH (M.A.J., A.M., S.F.Z.).ORCID https://orcid.org/0000-0002-7750-1132
Syed F ZaidiDepartment of Neurology, University of Toledo College of Medicine and Life Sciences, OH (M.A.J., A.M., S.F.Z.).ORCID https://orcid.org/0000-0003-4967-1801
Alejandro M SpiottaDepartment of Neurosurgery, Medical University of South Carolina, Charleston (A.M.S., K.P.K., J.L., Z.H., S.A.K.).
Kimberly P KicielinskiDepartment of Neurosurgery, Medical University of South Carolina, Charleston (A.M.S., K.P.K., J.L., Z.H., S.A.K.).ORCID https://orcid.org/0000-0003-0460-6280
Jonathan LenaDepartment of Neurosurgery, Medical University of South Carolina, Charleston (A.M.S., K.P.K., J.L., Z.H., S.A.K.).
Zachary HubbardDepartment of Neurosurgery, Medical University of South Carolina, Charleston (A.M.S., K.P.K., J.L., Z.H., S.A.K.).ORCID https://orcid.org/0000-0002-5643-9480
Osama O ZaidatDepartment of Neurology, Mercy Health St Vincent Medical Center, Toledo, OH (O.O.Z.).ORCID https://orcid.org/0000-0003-4881-4698
Colin P DerdeynDepartment of Radiology, University of Virginia, Charlottesville (C.P.D.).ORCID https://orcid.org/0000-0002-5932-2683
Thanh N NguyenDepartment of Neurology, Boston Medical Center, Boston University School of Medicine, MA (A.H., T.N.N.).ORCID https://orcid.org/0000-0002-2810-1685
Sami Al KasabDepartment of Neurosurgery, Medical University of South Carolina, Charleston (A.M.S., K.P.K., J.L., Z.H., S.A.K.).ORCID https://orcid.org/0000-0001-8909-9761
Ramesh GrandhiDepartment of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City (S.N., R.G.).ORCID https://orcid.org/0000-0001-9000-6083

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe RESCUE-ICAS study (Registry of Emergent Large-Vessel Occlusion due to Intracranial Stenosis) demonstrated that patients undergoing acute stenting of intracranial atherosclerosis with large-vessel occlusion after mechanical thrombectomy had better outcomes than those undergoing mechanical thrombectomy alone. We present 2 secondary analyses of RESCUE-ICAS to evaluate intracranial stenting among patients who achieved successful reperfusion.

methodsFrom a prospective observational cohort of 25 stroke centers (2022-2023), patients with acute intracranial occlusion, National Institutes of Health Stroke Scale score ≥6, and 50% to 99% residual stenosis or occlusion after endovascular thrombectomy were included. In the first analysis, we compared patients with stenting versus those without stenting from among those patients with a final modified Thrombolysis in Cerebral Infarction score of 2B-3. In the second analysis, we compared patients who underwent stenting with those who did not from among the patients with a Thrombolysis in Cerebral Infarction (TICI) score of 2B-3 before stenting. The odds of a favorable 90-day mRS (0-2) and 24-hour MRI infarct volume <30 mL were assessed using multivariable logistic regression. We also examined the rates of symptomatic ICH and death at 90 days in these cohorts.

resultsOverall, 351 (84.2%) patients had successful reperfusion, with 181 (51.7%) undergoing stenting. More patients who underwent acute stenting achieved an mRS score of 0 to 2 at 90 days (adjusted odds ratio, 1.88;

conclusionsAmong both the cohort with final successful reperfusion and the cohort with initial successful reperfusion after mechanical thrombectomy alone, intracranial stenting was associated with better long-term clinical and radiographic outcomes, without higher morbidity and mortality. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05403593.

Indexed as

angioplastyischemic strokemagnetic resonance imagingreperfusionthrombectomy

Identifiers

PMID41815302
PMCPMC12959446

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