Evidence map›Paper›PMID 41815134›Full record

ArticleTranslational cancer research2026

Prognostic significance of lymph node-related indices and a novel nomogram for rectal cancer patients with synchronous liver metastases after the preoperative chemoradiotherapy: a population-based study.

Kexing Xi, Youbo Wu, Xiaowen Sun, Changzheng Du, Feng Wang, Jialiang Liu, Yanjiang Yin, Yutong Wang, Jiaxiang Liu, Guoxin Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kexing XiCancer Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Youbo WuMedical College of Jiaying University, Meizhou, China.
Xiaowen SunCancer Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Changzheng DuCancer Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Feng WangCancer Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Jialiang LiuCancer Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Yanjiang YinCancer Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Yutong WangCancer Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Jiaxiang LiuCancer Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Guoxin LiCancer Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patient outcomes in rectal cancer with synchronous liver metastases remain heterogeneous, underscoring the need for reliable prognostic factors to guide individualized treatment strategies. This study sought to assess the influence of lymph node-related indices on the survival of rectal cancer patients with synchronous liver metastases who underwent preoperative chemoradiotherapy and to construct a novel nomogram for this patient population. Methods: Data on rectal cancer patients with synchronous liver metastases who underwent preoperative chemoradiotherapy between 2010 and 2019 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. X-tile software was employed to determine the optimal cutoff point of lymph node-related indices. The Kaplan-Meier method and log-rank test were used to assess survival differences. Cox univariate and multivariate analyses were conducted to identify the prognostic factors for overall survival (OS). We constructed a novel nomogram to predict individual survival probability. The concordance index (C-index) and calibration curve were used to determine the predictive accuracy and discriminative ability of the nomogram. Results: A total of 547 rectal cancer patients with synchronous liver metastases were enrolled. The OS of patients with total number of lymph nodes (TLN) <7 was significantly worse than that of patients with TLN ≥7 (3-year OS rate: 46.6% Conclusions: Lymph node (LN)-related indices are significant prognostic factors for OS in rectal cancer patients with synchronous liver metastases, offering insights into survival prediction and enabling personalized treatment strategies.

Indexed as

liver metastasesnumber of examined lymph nodesnumber of negative lymph nodes (NLN)number of positive lymph nodes (PLN)Rectal cancer

Identifiers

PMID41815134
PMCPMC12971568

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