ArticleFrontiers in human neuroscience2026
Exploring cortical excitability modulation to promote cognitive resilience in aging: an rTMS study protocol.
Article in Frontiers in human neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Changes in cortical plasticity induced by paired associative stimulation in people with mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis.Frontiers in neural circuits · 2026Pooled it
- Effects of Transcranial Direct Current Stimulation Combined with Peripheral Electrical Stimulation on Upper Limb Function Recovery in Stroke: A Systematic Review and Meta-Analysis.Brain sciences · 2026Review
- Long-Lasting Changes of Repeated Anodal Transcranial Direct Current Stimulation in Decreasing Chronic Pain in Patients with Multiple Sclerosis: A Case Series.Brain sciences · 2026Article
- Transcranial Magnetic Stimulation over the Left Inferior Parietal Lobule Facilitates Early-Stage Processing During Natural Chinese-English Bilingual Reading.Brain sciences · 2026Article
- Association Between the Color Kanji Pick-Out Test App Performance and Cognitive Frailty as a Potential Early Screening Marker for Cognitive Decline.Geriatrics (Basel, Switzerland) · 2026Article
- Functional ultrasound imaging in preclinical brain stimulation: from multimodal readouts to closed-loop neuromodulation.Frontiers in neuroscience · 2026Review
- Transcranial magnetic stimulation from healthy brain aging to Alzheimer's disease: a review on mechanisms, therapeutic potential, and future clinical directions.Frontiers in aging neuroscience · 2026Review
- Determinants of Post-Stroke Cognitive Impairment After Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.Neuropsychiatric disease and treatment · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Promoting cognitive resilience in aging is essential for preserving autonomy and quality of life. Non-invasive brain stimulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), have shown promise in enhancing neuroplasticity and cognitive functioning in older adults. This study protocol outlines the methodological framework for an investigation designed to examine whether high-frequency rTMS applied over the left dorsolateral prefrontal cortex (DLPFC) can modulate cortical excitability (CE) and characterize changes in cognitive and emotional functioning in healthy older individuals. The protocol provides detailed descriptions of stimulation parameters, safety monitoring procedures, and assessment tools. Cortical excitability will be measured using transcranial magnetic stimulation-derived motor-evoked potentials (MEPs), while cognitive and emotional outcomes will be assessed with a comprehensive neuropsychological battery. A preliminary feasibility phase with four participants was conducted to refine procedures and assess tolerability, safety, and data acquisition reliability. The study aims to determine the feasibility and signal characterization of cortical excitability modulation within a crossover framework and to explore the potential relationship between CE modulation and behavioral outcomes. Observations from this pilot phase will inform procedural refinement and the design of a larger ongoing trial.
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